2. The mechanisms of nsaids Disturbance of cell membranes Phospholipase inhibitors Corticosteroids Phosphol Fatty acid substitution(diet)(Arachidonic acid Lipoxygenase inhibitors - Lipoxygenase Cyclo-oxygenase- NSAID Receptor level antagonists Leukotriene LTB LTC//D/Es (Prostaglandin Thromboxane Prostacyclin Alteration of vascular attraction permeability, bronchial activation constriction, increased Leukocyte modulation secretion Colchicine Inflammation Bronchospasm Inflammation mucous plugging Copyright @2006 by The McGraw-Hill Companies, Inc.2. The mechanisms of NSAIDs