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Name Section Question 4 Working in mice, you discover a gene, LCl, that when mutant decreases the incidence of cancer in mice. This gene is normally expressed in the lymphatic tissues of mice. You know the sequence of this gene, and you really want to see if there is a similar gene is in humans. So, you set out to find the human homolog of LC1 by screening a human library a) What kind of human library would you use? Explain b)How would you screen the human library for the homolog of LC1? 7012Fall2003Name:___________________________________ Section:_____ 7.012 Fall 2003 5 Question 4 Working in mice, you discover a gene, LC1, that when mutant decreases the incidence of cancer in mice. This gene is normally expressed in the lymphatic tissues of mice. You know the sequence of this gene, and you really want to see if there is a similar gene is in humans. So, you set out to find the human homolog of LC1 by screening a human library. a) What kind of human library would you use? Explain. b) How would you screen the human library for the homolog of LC1?
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