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史晶洁,等·人乳头瘤病毒样颗粒组装研究进展 2160-2167 [31] Hanslip S J, Zaccai N R, Middelberg A P, Falconer R [25] Ishii Y, Tanaka K, Kanda T. Mutational analysis of J. Assembly of human papillomavirus type-16 virus- human papillomavirus type 16 major capsid like particles: Multifactorial study of assembly and The cysteines affecting the intermolecular bonding and competing aggregation[J]. Biotechnol Prog, 2006,22 structure of LI-capsidsDJJ. Virology, 2003, 308(1): (2):554-560. 128-136. [32] Mukherjee S, Thorsteinsson M V, Johnston LB, De- [26] Shi L, Sanyal G, Luo Z, Ni A, Doshna S, Wang B, Phillips P A, Zlotnick A. A quantitative description of Graham T L, Wang N, Volkin D B. Stabilization of in vitro assembly of human papillomavirus 16 virus-like human papillomavirus virus-like particles by nonionic particles[J]. J Mol Biol, 2008, 381(1):229-237. surfactants[J]. J Pharm Sci, 2005, 94(7): 1538-1551. [33] Kirnbauer R. Taub J, Greenstone H,, Roden R. [27] Katakam M, Bell LN, Banga A K. Effect of surfac- Durst M, Gissmann L, Lowy D R, Schiller J T. Effi- tants on the physical stability of recombinant human cient self-assembly of human papillomavirus type 16 L1 growth hormone[J]. J Pharm Sci,1995,84(6):713- and L1-L2 into virus-like particles[J]. J Virol,1993 716 67(12):6929-6936 [28] Bam N B, Randolph T W, Cleland J L. Stability of [34] Ishii Y, Ozaki S, Tanaka K, Kanda T. Human papi- protein formulations: Investigation of surfactant lomavirus 16 minor capsid protein L2 helps capsomeres effects by a novel epr spectroscopic technique [J] assemble independently of intercapsomeric disulfide Pharm res,1995,12(1):2-11 bonding[J]. Virus Genes, 2005,31(3):321-328 [29] Arakawa T, Kita Y. Protection of bovine serum albu-[35]赵朴,郑玉姝,刘兴友.病毒样颗粒疫苗及载体的研究 min from aggregation by Tween 80[J]. J Pharm Sci 进展[J.中国生物制品学杂志,2009,22(5):515 000,89(5):646-651 [30] McCarthy M P, White W I, Palmer-Hill F, Koenig S, [36] Kanda T, Kondo K. Development of an HPV vaccine Suzich J A. Quantitative disassembly and reassembly for a broad spectrum of high-risk types[J]. Hum Vac- of human papillomavirus type 1l viruslike particles in cin,2009,5(1):43-45 vitro[J]. J Virol,1998,72(1):32-41 21994-2018ChinaAcademicJOurnalElectronicpUblishingHouse.Allrightsreservedhttp:/www.cnki.net2160-2167. [25]IshiiY,TanakaK,KandaT.Mutationalanalysisof humanpapillomavirustype16majorcapsidproteinL1: Thecysteinesaffectingtheintermolecularbondingand structureofL1-capsids[J].Virology,2003,308(1): 128-136. [26]ShiL,SanyalG,LuoZ,NiA,DoshnaS,WangB, GrahamT L,Wang N,VolkinD B.Stabilizationof humanpapillomavirusvirus-likeparticlesbynon-ionic surfactants[J].JPharmSci,2005,94(7):1538-1551. [27]Katakam M,BellLN,BangaA K.Effectofsurfac- tantsonthephysicalstabilityofrecombinanthuman growthhormone[J].JPharmSci,1995,84(6):713- 716. [28]Bam N B,RandolphT W,ClelandJL.Stabilityof protein formulations: Investigation of surfactant effectsbya noveleprspectroscopictechnique[J]. PharmRes,1995,12(1):2-11. [29]ArakawaT,KitaY.Protectionofbovineserumalbu- minfromaggregationbyTween80[J].JPharmSci, 2000,89(5):646-651. [30]McCarthyMP,WhiteWI,Palmer-HillF,KoenigS, SuzichJA.Quantitativedisassemblyandreassembly ofhumanpapillomavirustype11viruslikeparticlesin vitro[J].JVirol,1998,72(1):32-41. [31]HanslipSJ,ZaccaiNR,MiddelbergAP,FalconerR J.Assemblyofhumanpapillomavirustype-16virus- likeparticles: Multifactorialstudy ofassembly and competingaggregation[J].BiotechnolProg,2006,22 (2):554-560. [32]MukherjeeS,ThorsteinssonM V,JohnstonLB,De- PhillipsPA,ZlotnickA.Aquantitativedescriptionof invitroassemblyofhumanpapillomavirus16virus-like particles[J].JMolBiol,2008,381(1):229-237. [33]KirnbauerR,TaubJ,Greenstone H,,Roden R, DürstM,GissmannL,LowyDR,SchillerJT.Effi- cientself-assemblyofhumanpapillomavirustype16L1 andL1-L2intovirus-likeparticles[J].JVirol,1993, 67(12):6929-6936. [34]IshiiY,OzakiS,TanakaK,KandaT.Humanpapil- lomavirus16minorcapsidproteinL2helpscapsomeres assembleindependently ofintercapsomeric disulfide bonding[J].VirusGenes,2005,31(3):321-328. [35]赵朴,郑玉 姝,刘 兴 友.病毒样颗粒疫苗及载体的研 究 进展[J].中国生物制品学杂志,2009,22(5):515- 517. [36]KandaT,KondoK.Developmentofan HPVvaccine forabroadspectrumofhigh-risktypes[J].HumVac- cin,2009,5(1):43-45. 2期 史晶洁,等.人乳头瘤病毒样颗粒组装研究进展 · 752 ·
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