Synthesis of Amines Reductive aminations occur in biological pathways Biosynthesis of amino acid proline Glutamate 5-semialdehyde undergoes internal imine formation to give 1-pyrrolinium-5-carboxylate 1-pyrrolinium-5-carboxylate is reduced by nucleophilic addition of hydride ion by NADH H H2O NADH NAD+ CO. H Glutamate 1-Pyrrolinium Proline 5-semialdehyde 5-carboxylate▪ Reductive aminations occur in biological pathways ▪ Biosynthesis of amino acid proline ▪ Glutamate 5-semialdehyde undergoes internal imine formation to give 1-pyrrolinium-5-carboxylate ▪ 1-pyrrolinium-5-carboxylate is reduced by nucleophilic addition of hydride ion by NADH Synthesis of Amines