· Other major matrⅸ k-structure proteins · Key length scales ter of collagen fibrils 50-200nm o diameter of collagen fibers 05-5pm o diameter of collagen triple helices: o diameter ofof collagen chain o length of collagen triple helix 300nm Adhesion proteins Collagen I fibril ligand binding site map H!! lal Binds to surface recep:Drs on 400000 Binds to Heparan sulfate prote Laminin Lodish) o Adhesion proteins designed to bind to structural ECM components, and present binding sites to receptors o Adhesion proteins can present multiple binding sites for different receptors that work Lecture 3- Biological Recognition 3of15• Other major matrix-structure proteins: o Elastin • Key length scales: o diameter of collagen fibrils: 50-200 nm o diameter of collagen fibers: 0.5-5 µm o diameter of collagen triple helices: o diameter of of collagen chain: o length of collagen triple helix: 300 nm • Adhesion proteins o Complexity of adhesion proteins (SLIDE) Collagen I fibril ligand binding site map laminin structure 1 (from Lodish) o Adhesion proteins designed to bind to structural ECM components, and present binding sites to receptors o Adhesion proteins can present multiple binding sites for different receptors that work in synergy Lecture 3 – Biological Recognition 3 of 15