Potential transduction mechanisms involving changes in molecular conformationd Shear-stress induced conformational 888888888885888888 changes in transmembrane proteins Sensing proteins Forces tethered to the csK exerted by or at focal adhesion ECM or CSK sites attachmentsPotential transduction mechanisms involving� changes in molecular conformation� Shear-stress induced conformational changes in transmembrane proteins tethered to the CSK sites “Sensing” proteins or at focal adhesion Forces exerted by ECM or CSK attachments