How to study antibiotics and drug resistant (you may hand the homework before the midterm exams) Mechanisms of Target antibiotics Spectrum Bacterial Mechanisms Antibiotics (Narrow or infections of drug Broad) resistant Inhibit cell wall synthesis Inhibit protein synthesis Inhibit nucleic acid synthesis Inhibit metabolism Mechanisms of drug resistant out lines you may add more details 1. Altered permeability 2. Inactivation of the antibiotic 3. Mutation in the target site 4. Replacement of a sensitive enzyme with a resistant enzymeMechanisms of Antibiotics Target antibiotics Spectrum (Narrow or Broad) Bacterial infections Mechanisms of drug resistant Inhibit cell wall synthesis Inhibit protein synthesis Inhibit nucleic acid synthesis Inhibit metabolism Mechanisms of drug resistant (out lines, you may add more details) : 1. Altered permeability 2. Inactivation of the antibiotic 3. Mutation in the target site. 4. Replacement of a sensitive enzyme with a resistant enzyme How to study antibiotics and drug resistant (you may hand the homework before the midterm exams) 9