DNA DNA Quinolones Rifampin mRNA 30S 30 mRNA 30S Poo Tetracycline Protein synthesis GTP tmet-RNA Polyribosome translocation Protein 50S Pool 30S initiation complex Peptide band tormation 50S 70S initiation AA-IRNA complex AA 30S mRNA Aminoglycosides Chloramphenicol such as: +508 Erythromycin Streptomycin Clindamycin fmet-tRNA Gentamicin 抗菌作用机理：与细菌50S结合，抑制肽酰基转移酶和移位 酶；促使AA-tRNA从核糖体上解离，从而抑制蛋白质合成。 抗菌作用机理：与细菌50S结合，抑制肽酰基转移酶和移位 酶；促使AA-tRNA从核糖体上解离，从而抑制蛋白质合成