Antibiotics that may have activity against P. aeruginosa include: aminoglycosides(gentamicin, amikacin Treatment tobramycin but not kanamycin quinolones(ciprofloxacin, levofloxacin, but not moxifloxacin cephalosporins (ceftazidime, cefepime cefoperazone, cefpirome, ceftobiprole, but not cefuroxime, cefotaxime, or ceftriaxone antipseudomonal penicillins: carboxypenicillins (carbenicillin and ticarcillin) and ureidopenicillins(mezlocillin azlocillin and piperacillin). P aeruginosa is intrinsically resistant to all other penicillins. carbapenems(meropenem imipenem doripenem, but not ertapenem polymyxins (polymyxin B and colistin)[42] monobactams (aztreonam) PS: Fluoroquinolone is one of the few antibiotics widely effective against P aeruginosa >avoid the development of resistant strains Infection is superficial and limited >topical gentamicin or colistin may be usedTreatment • Antibiotics that may have activity against P. aeruginosa include: • aminoglycosides (gentamicin, amikacin, tobramycin, but not kanamycin ) • quinolones (ciprofloxacin, levofloxacin, but not moxifloxacin ) • cephalosporins (ceftazidime, cefepime, cefoperazone, cefpirome, ceftobiprole, but not cefuroxime, cefotaxime, or ceftriaxone ) • antipseudomonal penicillins: carboxypenicillins (carbenicillin and ticarcillin), and ureidopenicillins (mezlocillin, azlocillin, and piperacillin). P. aeruginosa is intrinsically resistant to all other penicillins . • carbapenems (meropenem, imipenem, doripenem, but not ertapenem ) • polymyxins (polymyxin B and colistin)[42] • monobactams (aztreonam ) • P.S: Fluoroquinolone is one of the few antibiotics widely effective against P. aeruginosa → avoid the development of resistant strains. Infection is superficial and limited → topical gentamicin or colistin may be used