Etiology Uric acid is an end-stage by-product of purine metabolism. Human s remove uric acid primarily by renal excretion. ( the saturation level of 6.8 mg/dL) Ninety percent of patients with gout... underexcretion The remaini ng patients.overproduction. In rare cases, overproduction., due to a genetic disorder ( hypoxa nthine-guanine phosphoribosyl transferase.次黄吟鸟酸长精基转移 deficie ncy, glucose-6-phosphatase deficiency, fructose 1-phosphate ald olase醛缩酶 deficiency) Chronic urate nephropathy can result from the deposition of urate c rystals in the medullary interstitium and pyramids, resulting in an inf lammatory reaction that can lead to fibrotic changes 浙医二院5 浙医二院 Etiology Uric acid is an end-stage by-product of purine metabolism. Human s remove uric acid primarily by renal excretion. (the saturation level of 6.8 mg/dL ) Ninety percent of patients with gout … underexcretion. The remaini ng patients …overproduction. In rare cases, overproduction .., due to a genetic disorder. ( hypoxa nthine-guanine phosphoribosyl transferase次黄嘌呤鸟嘌呤磷酸核糖基转移酶 deficie ncy , glucose-6-phosphatase deficiency , fructose 1-phosphate ald olase醛缩酶 deficiency) Chronic urate nephropathy can result from the deposition of urate c rystals in the medullary interstitium and pyramids, resulting in an inf lammatory reaction that can lead to fibrotic changes