Aims 1.To know of: (1)The definition of drugs,new drug and bioavailability. (2)The components of preclinical drug development. 2.To master (1)The definition of GCP. (2)The determination of minimum first dose. (3)The purpose and significance Phase II clinical trial. (4)The purpose and significance of human bioavailability test. 2019/8/28 Institute of clinical pharmacology,AHMU 3Aims 1. To know of : (1) The definition of drugs, new drug and bioavailability. (2) The components of preclinical drug development. 2. To master : (1) The definition of GCP . 2019/8/28 Institute of clinical pharmacology, AHMU 3 (2) The determination of minimum first dose. (3) The purpose and significance Phase II clinical trial. (4) The purpose and significance of human bioavailability test