美国发现“无敌细菌” 所有抗生素无效 2016-05-2909:53 来源：凤凰网 我有话说 Escherichia coli Harboring mcr-1 and blacixM on a Novel IncF Plasmid:First report of mcr-1 in the USA The recent discovery of a plasmid-borne colistin resistance gene,mcr-1,heralds the emergence of truly pan-drug resistant bacteria (1).The gene has been found primarily in Escherichia coli, but has also been identified in other members of the Enterobacteriaceae from human,animal, food and environmental samples on every continent(2-5).In response to this threat,starting in May 2016,all extended-spectrum B-lactamase (ESBL)-producing E.coli clinical isolates submitted to the clinical microbiology laboratory at the Walter Reed National Military Medical Center (WRNMMC)were tested for resistance to colistin by E-test.Herein we report the presence of mcr-I in an E.coli cultured from a patient with a urinary tract infection (UTD in the United States. AAC Accepted Manuscript Posted Online 26 May 2016 Antimicrob.Agents Chemother.doi:10.1128/AAC.01103-16 Copyright 2016 McGann et al