进，虽然这可能帮助受维生素A缺乏症困扰的人群。 3展望 黄金大米有望解决世界欠发达国家维生素A缺乏现象。2005年，全球有122个国家 的1.9亿儿童和0.19亿孕妇缺乏维生素A。[3]每年导致导致1-2百万人死亡，五十 万例永久失明，和数百万干眼症[4]一些国家通过口服维生素A药剂来缓解这一问 题。[5]但有些国家没有这种营养补充项目，许多这些国家的儿童以稻米为主食 因此转基因稻米就成为一种方便链接的补充维生素A的手段，就像通过碘盐预防 碘缺乏症一样。 [参考文献] [1]Ye,X;Al-Babili,S;Kloti,A;Zhang,J;Lucca,P;Beyer,P;Potrykus,I. Engineering the provitamin A (beta-carotene)biosynthetic pathway into (carotenoid-free)rice endosperm.Science.2000,287(5451):303-5. [2]Black RE et al.,Maternal and child undernutrition:global and regional exposures and health consequences,The Lancet,2008,371(9608),p.253 [3]Paine,Jacqueline A;Shipton,Catherine A;Chaggar,Sunandha;Howells,Rhian M; Kennedy,Mike J;Vernon,Gareth;Wright,Susan Y;Hinchliffe,Edward et al. Improving the nutritional value of Golden Rice through increased pro-vitamin A content.Nature Biotechnology.2005,23 (4):482-7.doi:10.1038/nbt1082.PMID 15793573. [4]Humphrey,J.H.;West,K.P.Jr;Sommer,A.Vitamin A deficiency and attributable mortality in under-5-year-olds (PDF).WHO Bulletin.1992,70:225-232. [5]Vitamin A Global Initiative.1997.A Strategy for Acceleration of Progress in Combating Vitamin A Deficiency进，虽然这可能帮助受维生素 A 缺乏症困扰的人群。 3 展望 黄金大米有望解决世界欠发达国家维生素A缺乏现象。2005年，全球有122个国家 的1.9亿儿童和0.19亿孕妇缺乏维生素A。[3]每年导致导致1-2百万人死亡，五十 万例永久失明，和数百万干眼症[4]一些国家通过口服维生素A药剂来缓解这一问 题。[5]但有些国家没有这种营养补充项目，许多这些国家的儿童以稻米为主食 因此转基因稻米就成为一种方便链接的补充维生素A的手段，就像通过碘盐预防 碘缺乏症一样。 [参考文献] [1] Ye, X; Al-Babili, S; Klöti, A; Zhang, J; Lucca, P; Beyer, P; Potrykus, I. Engineering the provitamin A (beta-carotene) biosynthetic pathway into (carotenoid-free) rice endosperm. Science. 2000, 287 (5451): 303–5. [2] Black RE et al., Maternal and child undernutrition: global and regional exposures and health consequences, The Lancet, 2008, 371(9608), p. 253. [3] Paine, Jacqueline A; Shipton, Catherine A; Chaggar, Sunandha; Howells, Rhian M; Kennedy, Mike J; Vernon, Gareth; Wright, Susan Y; Hinchliffe, Edward et al. Improving the nutritional value of Golden Rice through increased pro-vitamin A content. Nature Biotechnology. 2005, 23 (4): 482–7. doi:10.1038/nbt1082. PMID 15793573. [4] Humphrey, J.H.; West, K.P. Jr; Sommer, A. Vitamin A deficiency and attributable mortality in under-5-year-olds (PDF). WHO Bulletin. 1992, 70: 225–232. [5] Vitamin A Global Initiative. 1997. A Strategy for Acceleration of Progress in Combating Vitamin A Deficiency