Enzymes Accelerate Reactions by Facilitating the Formation of the Transition State过渡态 How quickly enzymes accelerate this equilibrium!! How can we explain the rate enhancement in terms of thermodynamics? Enzymes accelerate reactions by specific binding of transition state and then decreasing the activation energy. Transition state,X+ △Gt(uncatalyzed) The transition state: Substrate a transitory molecular △G structure过渡分子结构that is for the reaction no longer the substrate but is not yet the product.既不是底物， Product 也不是产物。 Reaction progress→Enzymes Accelerate Reactions by Facilitating the Formation of the Transition State 过渡态 The transition state： － a transitory molecular structure 过渡分子结构that is no longer the substrate but is not yet the product. 既不是底物， 也不是产物。 How quickly enzymes accelerate this equilibrium!! How can we explain the rate enhancement in terms of thermodynamics? Enzymes accelerate reactions by specific binding of transition state and then decreasing the activation energy