Cholestatic Jaundice(2) Intra-hepatic cholestasis: bile production and excretion\ infection, drugs Changes in the structure and function of the hepatic cell membrane Dysfunction of microtubule and microfilament The permeability of bile capillary membrane and tight junction Disorder in the bile acid metabolismCholestatic Jaundice (2) • Intra-hepatic cholestasis: bile production and excretion↓ infection, drugs. • Changes in the structure and function of the hepatic cell membrane • Dysfunction of microtubule and microfilament • The permeability of bile capillary membrane and tight junction ↑ • Disorder in the bile acid metabolism