疫情以来，虽然新亚型不断出现，但英国的这一新突变株的传播能力异 常恐怖。 这一毒株从9月在英国东南部出现，在英国迅速蔓延，目前已经成为 伦敦地区的主要毒株。该病毒株在英格兰东南部的新感染病例中占43%； 在英格兰东部占59%；在伦敦占62%。截止到12月10日英国已检测出 46,710个该毒株的感染者。 COG Table 1a.Priority mutations being tracked by COG-UK Mutation Predominant Reasons for tracking Cumulative Number over Lineage number in UK last 28 days (13/11/2020 10/12/20201 D614G 81 Moderate effect on 118,906 11,447 transmissibility A222V B1.177 Fast growing lineage but no 46,710 7,8$ evidence of mutation effect N439K B.1.141 1)Increased binding affinity to 3,320 246 B.1.258 hACE2 receptor 2)Escape to some mAbs 469-70 B.1.1 1)Evasion immune response 3504 1228 B.1.258 2)Diagnostic failure in some assays targeting the S gene including the three-target TagPath assay and the two-target Biofire assay N501Y B.1.1.7 Fast growing lineage increased 2,057 1,182 binding affinity to hACE2 receptor N501Y+ 8.1.1.7 Likely to maintain characteristics 1,524 1034 △69-70 described for N501Y and 69-70del N439K+ B.1.258 Likely to maintain characteristics 1,895 176 △69-70 described for N439Y and 69-70del Y453F B.1.1 1)Increase binding affinity to B.1.1.298 hACE2 receptor 2)Escape to some mAbs Human/mink associated umulative number as of December 15 based on data deposited into CLIMB.Caution is reauired the data will not include information from the last 2 weeks.疫情以来，虽然新亚型不断出现，但英国的这一新突变株的传播能力异 常恐怖。 这一毒株从 9 月在英国东南部出现，在英国迅速蔓延，目前已经成为 伦敦地区的主要毒株。该病毒株在英格兰东南部的新感染病例中占 43%； 在英格兰东部占 59%；在伦敦占 62%。截止到 12 月 10 日英国已检测出 46,710 个该毒株的感染者