Pharmacological division of cholinergic vs.adrenergic neurotransmission All preganglionic and parasympathetic postganglionic neurons use acetylcholine as neurotransmitter.Ach is the neurotransmitter at ganglia, nmj,and muscarinic tissue synapses. Most postganglionic sympathetic neurons use norepinephrine which is an adrenergic neurotransmitter. There are exceptions:Cholinergic transmission in sympathetic system all ganglia,adrenal medulla,sweat glads(muscarinic).Dopaminergic innervation in sympathetic system-renal blood vessels.• All preganglionic and parasympathetic postganglionic neurons use acetylcholine as neurotransmitter. Ach is the neurotransmitter at ganglia, nmj, and muscarinic tissue synapses. • Most postganglionic sympathetic neurons use norepinephrine which is an adrenergic neurotransmitter. Pharmacological division of cholinergic vs. adrenergic neurotransmission • There are exceptions: Cholinergic transmission in sympathetic system – all ganglia, adrenal medulla, sweat glads (muscarinic). Dopaminergic innervation in sympathetic system – renal blood vessels