上浒文通大警 SHANGHAI JIAO TONG UNIVERSITY G DNA-Binding Proteins Most DNA-binding proteins interact with DNA in a sequence- specific manner Specificity provided by interactions between amino acid side chains and chemical groups on the bases and sugar- phosphate backbone of DNA Major groove of DNA is the main site of protein binding Inverted repeats frequently are binding site for regulatory proteins CHEN FENG,School of Life Sciences and Biotech.CHEN FENG，School of Life Sciences and Biotech. DNA-Binding Proteins Most DNA-binding proteins interact with DNA in a sequence￾specific manner Specificity provided by interactions between amino acid side chains and chemical groups on the bases and sugar– phosphate backbone of DNA Major groove of DNA is the main site of protein binding Inverted repeats frequently are binding site for regulatory proteins