BEH.462/3. 962J Molecular Principles of Biomaterials Spring 2003 2. Therapeutic devices (SLIDE) rug delivery 1. small molecules, peptides, and proteins, and dNa (gene therapy) b. tissue engineering/regenerative medicine Porous matrix VEGF Time(days) 3. Analy 1. glucose sensors 2. toxin detection or something in between (1),(2), and (3): (SLIDE) Cells organized into tissue-like structures Culture ilter control一■■■ 3 mm Perfusion through "tissue Fig. 2. A microfabricated bioreactor for perfus ngi- nels. (C)Hepatocytes seeded onto the scaffold of the eered in vitro(54, 55).(A) growing attached to he inside walls of the 3D structures that are reminiscent of liver cords Bile ulture medium flows across the top of the scaffold nctions can be seen with high-power microscopy(54, 55). Live cells are 0. 2-mm-thick silicon-chip scaffold etched with 03-mm-diameter chan- the bioreactor channels [Illustration: Preston Morrighanl (Prof. Giffith's lab) Overview of topics and viewpoint (syllabus summary )(SLIDE) 1. Biodegradable polymeric solids 2. Controlled release from solid polymers 4. bioceramics and biocomposites 5. hybrid biological'synthetic molecules 6. stimuli-responsive biomaterials -we 'll try to remain complementary to other biomaterials courses 2.79J/3. 96J/BE.441J Biomaterials-Tissue Interactions BE. 342 Molecular Structure of Biological Materials Lecture 1-IntroductionBEH.462/3.962J Molecular Principles of Biomaterials Spring 2003 2. Therapeutic devices (SLIDE) a. Drug delivery 1. small molecules, peptides, and proteins, and DNA (gene therapy) b. tissue engineering/regenerative medicine (Mooney2 ) 3. Analytical devices a. Biosensors 1. glucose sensors 2. toxin detection b. …or something in between (1), (2), and (3): (SLIDE) (Prof. Giffith’s lab3 ) Overview of topics and viewpoint (syllabus summary) (SLIDE) 1. Biodegradable polymeric solids 2. Controlled release from solid polymers 3. hydrogels 4. bioceramics and biocomposites 5. hybrid biological/synthetic molecules 6. stimuli-responsive biomaterials -we’ll try to remain complementary to other biomaterials courses: 2.79J/3.96J/BE.441J Biomaterials-Tissue Interactions BE.342 Molecular Structure of Biological Materials Lecture 1 – Introduction