Feature Tumor Suppressor Oncogenes G enes Function of normal Regulates cell growth Promotes cell growth version and proliferation; and proliferation some can induce apoptosis Mutation(at cell level) Recessive(both Dominant (only one copies of gene copy of gene mutated) inactivated) Effect of mutation Loss of function Gain of function Germline mutations Seen in most tumor Seen in only a few resulting in inherited suppressor genes oncogenes cancer syndromesFeature Tumor Suppressor Genes Oncogenes Function of normal version Regulates cell growth and proliferation; some can induce apoptosis Promotes cell growth and proliferation Mutation (at cell level) Recessive (both copies of gene inactivated) Dominant (only one copy of gene mutated) Effect of mutation Loss of function Gain of function Germline mutations resulting in inherited cancer syndromes Seen in most tumor suppressor genes Seen in only a few oncogenes