工型超敏反应参与的有关介质 TABLE 16-3 PRINCIPAL MEDIATORS INVOLVED IN TYPE I HYPERSENSITIVITY Mediator Effects Primary Histamine Increased vascular permeability;smooth-muscle contraction Serotonin Increased vascular permeability;smooth-muscle contraction Eosinophil chemotactic factor (ECF-A) Eosinophil chemotaxis Neutrophil chemotactic factor (NCF-A) Neutrophil chemotaxis Proteases Bronchial mucus secretion;degradation of blood-vessel basement membrane;generation of complement split products Secondary Platelet-activating factor Platelet aggregation and degranulation;contraction of pulmonary smooth muscles Leukotrienes (slow reactive substance of anaphylaxis, Increased vascular permeability:contraction of pulmonary SRS-A) smooth muscles Prostaglandins Vasodilation;contraction of pulmonary smooth muscles; platelet aggregation Bradykinin Increased vascular permeability;smooth-muscle contraction Cytokines IL-1 and TNF-a Systemic anaphylaxis;increased expression of CAMs on venular endothelial cells IL-2,IL-3,IL-4,IL-5,IL-6,TGF-B,and GM-CSF Various effects (see Table 12-1) Ⅰ型超敏反应参与的有关介质