l Water – non-polar molecules – Thermodynamically unfavorable _ decrease in entropy – Formation of rigid ice-like clathrate at interface – Dipole – induced dipole – Hydrophobic interactions _ association of apolar and non￾polar groups in aqueous environments Water Solute Interactionsl Water – non-polar molecules – Thermodynamically unfavorable _ decrease in entropy – Formation of rigid ice-like clathrate at interface – Dipole – induced dipole – Hydrophobic interactions _ association of apolar and non￾polar groups in aqueous environments Water Solute Interactions