Lecture 1 Class XVI 1.The classification of the adrenoceptor antagonist drugs ii.Pharmacologic effects of the a recepto antagonist drugs a.cardiovascular effects b.other effects iii.Clinical pharmacology of the a antagonist drugs iv.Specific agents:Phentolamine, Phenoxybenzamine,Prazosin Yohimbine v.Pharmacokinetic properties of the B antagonist drugs a.Abs orpti b.Bioavailability c.Distribution and clearance vi.Pharmacodynamics of the B R Antagonist Drugs a.Effects on the cardiovasular system b.Effects on the Respiratory Tract: c.Effects onthe Eye d.Metabolic and Endocrine Effects e.Intrinsic sympathomimetic activity (partial agonists) f effects not related to beta blockade vii.Clinical pha acolo r of the B ant aonist drugs viii.Clinical toxicity of the B antagonist drugs Sedative-Hypnotic Drugs Total hours required 2 Total Classes required Days of Study Tue Test= Wednesday Period ofStudy Week 1&2-First semester Lecture 1 Class XVI BASIC PHARMACOLOGY OF SEDATIVE- HYPNOTICS ii.CHEMICAL CLASSIFICATION iii.THE BENZODIAZEPINES BARBITURATES a.Pharmacokinetics i.Absorption ii.Distribution iii.Biotransformation iv.Excretion v.Factors Affecting BiodispositionLecture 1 Class XVI i. The classification of the adrenoceptor antagonist drugs ii. Pharmacologic effects of the  recepto antagonist drugs a. cardiovascular effects b. other effects iii.Clinical pharmacology of the  antagonist drugs iv. Specific agents: Phentolamine, Phenoxybenzamine,Prazosin ,Yohimbine v. Pharmacokinetic properties of the ß antagonist drugs a. Absorption b. Bioavailability c. Distribution and Clearance vi. Pharmacodynamics of the ß R Antagonist Drugs a. Effects on the cardiovasular system b. Effects on the Respiratory Tract: c. Effects on the Eye d. Metabolic and Endocrine Effects: e. Intrinsic sympathomimetic activity (partial agonists) f. Effects not related to Beta blockade vii. Clinical pharmacology of the ß antagaonist drugs viii. Clinical toxicity of the ß antagonist drugs Sedative-Hypnotic Drugs Total hours required = 2 Total Classes required = 1 Days of Study = Tue Test= Wednesday Period of Study = Week 1&2 –First semester Lecture 1 Class XVII i. BASIC PHARMACOLOGY OF SEDATIVE￾HYPNOTICS ii. CHEMICAL CLASSIFICATION iii. THE BENZODIAZEPINES & BARBITURATES a. Pharmacokinetics i. Absorption ii. Distribution iii. Biotransformation iv. Excretion v. Factors Affecting Biodisposition