Neonatal cholestasis a Neonatal cholestasis is defined a prolonged elevation of serum levels of conjugated bilirubin beyond the first 14 days of life Jaundice that appears after 2 wk of age progress after this time, or does not resolve at this time should be evaluated and a direct bilirubin level determinedNeonatal cholestasis ◼ Neonatal cholestasis is defined a sprolonged elevation of serum levels of conjugated bilirubin beyond the first 14 days of life. ◼ Jaundice that appears after 2 wk of age, progress after this time, or does not resolve at this time should be evaluated and a direct bilirubin level determined