Neonatal cholestasis May be due to infectious genetic metabolic, or undefined abnormalities mechanical obstuction of bile flow functional impairment of hepatic excretory function and bile secretion May be divided into extrahepatic and intrahepatic disease.Neonatal cholestasis ◼ May be due to infectious, genetic, metabolic, or undefined abnormalities ◼ mechanical obstuction of bile flow ◼ functional impairment of hepatic excretory function and bile secretion. ◼ May be divided into extrahepatic and intrahepatic disease