Stroma: 1.Fibroblasts in tumor: "Activated fibroblast" GF GF R activated 2.Genetic alteration: Juvenile polyposis syndrome(JPS),Cowen syndrome etc Dominant hereditary Stromal cells abnormality,Hamartoma High risk for colon cancer PTEN and others “Landscaper'”? “Stroma abnormal microenviroment” “Microenviroment of tumor-host interface” ZYY制作 ZYY制作 12 Stroma: 1. Fibroblasts in tumor: “Activated fibroblast” GF GF R activated 2. Genetic alteration: Juvenile polyposis syndrome (JPS), Cowen syndrome etc Dominant hereditary Stromal cells abnormality, Hamartoma High risk for colon cancer PTEN and others “Landscaper” “Stroma abnormal microenviroment” “Microenviroment of tumor-host interface