第3期 雷旭等：睡眠的同步EEG-fMRI研究述评 457 imaging with simultaneous EEG monitoring.American functional magnetic resonance imaging study.Neuroreport, Journal of Neuroradiology,24(10),1982-1988. 168)853-857. Valdes-Sosa,P.A.,Sanchez-Bornot,J.M.,Sotero,R.C.,Iturria- Wehrle,R.,Kaufmann,C.,Wetter,T.C.,Holsboer,F.,Auer, Medina,Y.,Aleman-Gomez,Y.,Bosch-Bayard,J.,...Ozaki, D.P.,Pollmacher,T.,Czisch,M.(2007).Functional T.(2009).Model driven EEG/fMRI fusion of brain microstates within human REM sleep:First evidence from oscillations.Human Brain Mapping.30(9),2701-2721. fMRI of a thalamocortical network specific for phasic Van der Helm,E.,Yao,J.,Dutt,S.,Rao,V.,Saletin,J.M., REM periods.European Journal of Neuroscience,25(3), Walker,M.P.(2011).REM Sleep Depotentiates Amygdala 863-871. Activity to Previous Emotional Experiences.Current Wilke,M.,Holland,S.K.,Ball,W.S.,Jr.(2003). B1olog21(23).2029-2032. Language processing during natural sleep in a 6-year-old Wehrle,R.,Czisch,M.,Kaufmann,C.,Wetter,T.C., boy,as assessed with functional MR imaging.American Holsboer,F,Auer,D.P.,&Pollmacher,T.(2005).Rapid Journal of Neuroradiology.24(1),42-44. eye movement-related brain activation in human sleep:A A Survey of Simultaneous EEG-fMRI on Sleep LEI Xu2,LIU Huan'2;LI Hong!23 (School of Psychology,Southwest University,Chongqing,400715,China) (Key Laboratory of Cognition and Personality,Chongqing,400715,China) Liaoning Normal University,Liaoning,116029,China) Abstract:Simultaneous EEG-fMRI integrates the complementary advantages of high-temporal-resolution EEG and high-spatial-resolution fMRI.As the traditional electrophysiological method was employed to sleep staging and event potential recording,simultaneous EEG-fMRI provides a non-invasive multimodal measurement of sleep and may clarify the cognition process in different consciousness condition.This review provides the recent development in spontaneous activity and sensory processing during sleep.We discussed some specific topics in sleep investigation,such as hardware,subjective and data process problems.The application of simultaneous EEG-fMRI has profound significance for elucidating the neural mechanism of conscious state conversion,and will provide new ideas for the diagnosis and treatment of the sleep disorders. Key words:multimodal;simultaneous EEG-fMRI;rapid-eye-movement sleep;non rapid-eye-movement sleep第 3 期 雷 旭等: 睡眠的同步 EEG-fMRI 研究述评 457 imaging with simultaneous EEG monitoring. American Journal of Neuroradiology, 24(10), 1982–1988. Valdes-Sosa, P. A., Sanchez-Bornot, J. M., Sotero, R. C., Iturria￾Medina, Y., Aleman-Gomez, Y., Bosch-Bayard, J., … Ozaki, T. (2009). Model driven EEG/fMRI fusion of brain oscillations. Human Brain Mapping, 30(9), 2701–2721. Van der Helm, E., Yao, J., Dutt, S., Rao, V., Saletin, J. M., & Walker, M. P. (2011). REM Sleep Depotentiates Amygdala Activity to Previous Emotional Experiences. Current Biology, 21(23), 2029–2032. Wehrle, R., Czisch, M., Kaufmann, C., Wetter, T. C., Holsboer, F., Auer, D. P., & Pollmächer, T. (2005). Rapid eye movement-related brain activation in human sleep: A functional magnetic resonance imaging study. Neuroreport, 16(8), 853–857. Wehrle, R., Kaufmann, C., Wetter, T. C., Holsboer, F., Auer, D. P., Pollmächer, T., & Czisch, M. (2007). Functional microstates within human REM sleep: First evidence from fMRI of a thalamocortical network specific for phasic REM periods. European Journal of Neuroscience, 25(3), 863–871. Wilke, M., Holland, S. K., & Ball, W. S., Jr. (2003). Language processing during natural sleep in a 6-year-old boy, as assessed with functional MR imaging. American Journal of Neuroradiology, 24(1), 42–44. A Survey of Simultaneous EEG-fMRI on Sleep LEI Xu1,2; LIU Huan1,2; LI Hong1,2,3 ( 1 School of Psychology, Southwest University, Chongqing, 400715, China) ( 2 Key Laboratory of Cognition and Personality, Chongqing, 400715, China) ( 3 Liaoning Normal University, Liaoning, 116029, China) Abstract: Simultaneous EEG-fMRI integrates the complementary advantages of high-temporal-resolution EEG and high-spatial-resolution fMRI. As the traditional electrophysiological method was employed to sleep staging and event potential recording, simultaneous EEG-fMRI provides a non-invasive multimodal measurement of sleep and may clarify the cognition process in different consciousness condition. This review provides the recent development in spontaneous activity and sensory processing during sleep. We discussed some specific topics in sleep investigation, such as hardware, subjective and data process problems. The application of simultaneous EEG-fMRI has profound significance for elucidating the neural mechanism of conscious state conversion, and will provide new ideas for the diagnosis and treatment of the sleep disorders. Key words: multimodal; simultaneous EEG-fMRI; rapid-eye-movement sleep; non rapid-eye-movement sleep