Changes in aortic pressure,cardiac energetics during aging SHANGHAI JIAO TONG UNIVERSITY 动脉硬化升高收缩压和扩大血压幅度， 而大动脉扩张有助于减轻这些影响 高龄者需要更高的心室收缩力来维持泵血量， 同时心脏的能效指标伴随加龄逐渐下降 140 Age 25 years Age 25 years Age 55 years Age 85 years ----Age 55 years 120 -.-..Age 85 years 120 100 80 80 60 60 40 40 20 20 20 40 6080 100 120 140 0.0 05 1.00.0 0.5 1.00.0 0.5 Ventricular blood volume(ml) Time(s) Age 25 years 2 -Age 85 years (with aortic dilatation) Age 55 years 160 ---Age 85 years (without aortic dilatation) Age 85 years 1.0 140 : 120 0.6 0.4 100 0.2 80 Ascending aorta Left brachial artery 0.0- SV EF Pes SW PVA 60 0.0 0.5 1.00.0 0.5 1.0 Left ventricular mechanical and energetic indices Time(s) [Liang F.Y.,Takagi S.,et al.Journal of Biomechanics.2009]17 动脉硬化升高收缩压和扩大血压幅度， 而大动脉扩张有助于减轻这些影响 SV EF Pes SW PVA 0.0 0.2 0.4 0.6 0.8 1.0 1.2 Age 25 years Age 55 years Age 85 years Normalized value Left ventricular mechanical and energetic indices 0 20 40 60 80 100 120 140 0 20 40 60 80 100 120 140 Age 25 years Age 55 years Age 85 years Ventricular blood pressure(mmHg) Ventricular blood volume(ml) Ees increases with age 高龄者需要更高的心室收缩力来维持泵血量， 同时心脏的能效指标伴随加龄逐渐下降 Changes in aortic pressure, cardiac energetics during aging 0 20 40 60 80 100 120 0.0 Blood pressure(mmHg) Pf Pf Pf Pb Pb Pb 0.0 0.5 0.5 1.0 0.5 1.0 Time(s) Age 25 years Age 55 years Age 85 years 1.0 0.0 [Liang F.Y., Takagi S., et al. Journal of Biomechanics. 2009] 60 80 100 120 140 160 1.0 Left brachial artery Blood pressure(mmHg) Age 85 years (with aortic dilatation) Age 85 years (without aortic dilatation) Ascending aorta 0.0 0.5 0.0 0.5 1.0 Time(s)