长春碱与长春新碱 Podophyllotoxin鬼臼毒素 1 白血病、奇金淋巴肉痛 老药新用一黄连素Berberine otc 天然产物载体是 Anticancer and Anti-diabetes 能粉念妇的业儿系，以康更 柔大微餐者指用于检做子以男聚老条上 New Wine In Old Bottle New Wine In Old Bottle wm 1 Dr. Robert L. Noble William Lipscomb 白血病、霍奇金淋巴肉瘤 长春碱与长春新碱 Podophyllotoxin 鬼臼毒素 O O O O OH H3CO OCH3 OH H H Podophyllum emodi var. chinense 小檗属植物鬼臼 Structure reported in 1951 by Hartwell and Schrecker 1 Etoposide 2 Teniposide O O O O OH H3CO OCH3 O H H O O OH HO H3C O O O O OH H3CO OCH3 O H H O O OH S HO 2013 FDA晚期乳腺癌 Maytansine Uni. Calif 天然产物-抗体-靶向给药 1972 老药新用—黄连素 Berberine Berberine Anticancer and Anti-diabetes N O O OMe OMe 臭名昭彰的镇定剂Thalidomide会导致孕妇的胎儿畸形，以致受到禁 用；但它也是治疗麻风病及AIDS的特效药物。 。 WHO于2002年宣布, 将重新启用DDT用于控制蚊子的繁殖以预防疟疾、登 革热、黄热病等在世界范围的卷土重来。 New Wine In Old Bottle New Wine In Old Bottle 桦木酸(Betulinic acid) Anti-HIV 与现有抗艾滋 药物作用靶点完全不同。 OH O OAc Acetylsalicyclic acid H H COOH HO H H New Wine In Old Bottle New Wine In Old Bottle Quinine approved by FDA in 2004 used for centuries for the treatment of malaria, fever, indigestion, mouth and throat diseases and cancer. In 1994, an oral formulation of pilocarpine was approved by the FDA to treat dry mouth (xerostomia). In 1998, the oral preparation was approved for the management of Sjogren's syndrome, an autoimmune disease that damages the salivary and lacrimal glands. O O N N CH3 N Pilocarpine O H N H H HO Quinine