REVIEWS 012) RN L3MB SETD2 1 PMTs EZH2-EZH M1 46 L3MB NA UTY KDMs DM6 DM4A D3(1) PBRM1 MAR BRDs HAT1- OA 1 A CECR -SIRT6-2 SIRT SP110-6 HDACs HDAC10-1(2) a DAC7_ DAC10-10 HDAC10-5 390 MAY 2012 VOLUME 11 www.nature.com/reviews/drugdisc 2012 Macmillan Publishers Limited.All rights reserve KDMs KDM4C KDM4A KDM4B KDM4DL KDM4D KDM5D KDM5C KDM5A KDM5B KDM6B JARID2 KDM6A UTY PHF2 PHF8 JHDM1D KDM2B KDM2A JMJD1C KDM3A KDM3B NO66 MINA JMJD5 KDM1B-2 KDM1B-1 KDM1A PRMT7(2) PRMT7(1) CARM1 PRMT8 PRMT1 PRMT3 PRMT6 PRMT2 DOT1L PRMT5 PRDM15 PRDM10 PRDM4 PRDM8 PRDM13 PRDM9 PRDM7 PRDM14 PRDM12 PRDM11 PRDM6 PRDM5 PRDM1 MDS1 PRDM16 PRDM2 SETDB2 SETDB1 EHMT1 EHMT2 SUV39H2 SUV39H1 SETMAR SETD1B SETD1A MLL4 MLL MLL3 EZH2-5 MLL2 EZH2-1 SETD5 EZH1 MLL5 SETD2 ASH1L WHSC1L1 WHSC1 SETD8 NSD1 PMTs SETD3 SUV420H2 SUV420H1 SETD7 SETD4 SETD6-1 SETD6-2 SMYD1 SMYD3 SMYD4 SMYD2 SMYD5 Nature Reviews | Drug Discovery SMARCA2-2 BAZ2A BAZ2B CECR2 BAZ1A TRIM66 TRIM24 TRIM33-1 TRIM33-2 TRIM28 SP100 SP140 SP140L SP110-1 SP110-6 SMARCA2-1 SMARCA4 PBRM1(6) PBRM1(4) PBRM1(5) PBRM1(3) PBRM1(1) ASH1L PBRM1(2) TAF1L(2) TAF1L(1) TAF1(1) ZMYND8 BPTF BRD3(2) BRD2(2) BRD4(2) BRDT(2) BRWD1(1) BRWD3(1) BRDT(1) BRD3(1) BRD2(1) BRD4(1) BRPF1-2 BRPF1-1 BRD1 BRPF3 BRD9 ATAD2B BRD7 CREBBP EP300 MLL BRWD3(2) PHIP(2) BRD8(1) BRWD1(2) BRD8(2) BAZ1B ATAD2 PHIP(1) KAT2B KAT2A ZMYND11 TAF1(2) BRDs HDAC10-1(2) HDAC10-1(1) HDAC10-5 HDAC10-2(1) HDAC6(1) HDAC6(2) HDAC9 HDAC5 HDAC4 HDAC7 HDAC2 HDAC1 HDAC3 HDAC8 HDAC11 SIRT7 SIRT6-2 SIRT6-1 SIRT4 SIRT6-4 SIRT5 SIRT3 SIRT1 SIRT2 HDACs KAT5 MYST1 MYST2 MYST3 MYST4 KAT2A KAT2B ELP3 NCOA3 CLOCK NCOA1 CREBBP EP300 ATAT1 TAF1 TAF1L HAT1 GTF3C4 HATs SCMH1(1) SCML2(1) L3MBTL2(2) MBTD1(2) SFMBT2(2) SFMBT1(2) L3MBTL2(1) MBTD1 (1) SFMBT1(1) SFMBT2(1) L3MBTL3(1) L3MBTL(1) L3MBTL4(1) L3MBTL4(3) SFMBT1(4) SFMBT2(4) L3MBTL(3) L3MBTL3(3) L3MBTL2(4) MBTD1(4) L3MBTL(2) L3MBTL4(2) L3MBTL3(2) SCMH1(2) SCML2(2) L3MBTL2(3) MBTD1(3) SFMBT1(3) SFMBT2(3) MBTs REVIEWS 390 | MAY 2012 | VOLUME 11 www.nature.com/reviews/drugdisc © 2012 Macmillan Publishers Limited. All rights reserved