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Schizo (本文编辑:王雪萍)ｚｏｓｔｅｒｓｕｂｕｎｉｔｖａｃｃｉｎｅｉｎａｄｕｌｔｓ７０ｙｅａｒｓｏｆａｇｅｏｒｏｌｄｅｒ［Ｊ］．Ｎ ＥｎｇｌＪＭｅｄ，２０１６，３７５（１１）：１０１９１０３２．ＤＯＩ：１０．１０５６／ＮＥＪ Ｍｏａ１６０３８００． ［２４］ＳｃｈｗａｒｚＴＦ，ＡｇｇａｒｗａｌＮ，ＭｏｅｃｋｅｓｃｈＢ，ｅｔａｌ．Ｉｍｍｕｎｏｇｅｎｉｃｉｔｙ ａｎｄｓａｆｅｔｙｏｆａｎａｄｊｕｖａｎｔｅｄｈｅｒｐｅｓｚｏｓｔｅｒｓｕｂｕｎｉｔｖａｃｃｉｎｅｃｏａｄ ｍｉｎｉｓｔｅｒｅｄｗｉｔｈｓｅａｓｏｎａｌｉｎｆｌｕｅｎｚａｖａｃｃｉｎｅｉｎａｄｕｌｔｓａｇｅｄ５０ｙｅａｒｓ ｏｒｏｌｄｅｒ［Ｊ］．ＪＩｎｆｅｃｔＤｉｓ，２０１７，２１６（１１）：１３５２１３６１．ＤＯＩ： １０．１０９３／ｉｎｆｄｉｓ／ｊｉｘ４８１． ［２５］ＭａｒéｃｈａｌＣ，ＬａｌＨ，ＰｏｄｅｒＡ，ｅｔａｌ．Ｉｍｍｕｎｏｇｅｎｉｃｉｔｙａｎｄｓａｆｅｔｙｏｆ ｔｈｅａｄｊｕｖａｎｔｅｄｒｅｃｏｍｂｉｎａｎｔｚｏｓｔｅｒｖａｃｃｉｎｅｃｏａｄｍｉｎｉｓｔｅｒｅｄｗｉｔｈ ｔｈｅ２３ｖａｌｅｎｔｐｎｅｕｍｏｃｏｃｃａｌｐｏｌｙｓａｃｃｈａｒｉｄｅｖａｃｃｉｎｅｉｎａｄｕｌｔｓ≥ ５０ｙｅａｒｓｏｆａｇｅ：ａｒａｎｄｏｍｉｚｅｄｔｒｉａｌ［Ｊ］．Ｖａｃｃｉｎｅ，２０１８，３６ （２９）：４２７８４２８６．ＤＯＩ：１０．１０１６／ｊ．ｖａｃｃｉｎｅ．２０１８．０５．１１０． ［２６］ＤｏｏｌｉｎｇＫＬ，ＧｕｏＡ，ＰａｔｅｌＭ，ｅｔａｌ．ＲｅｃｏｍｍｅｎｄａｔｉｏｎｓｏｆｔｈｅＡｄ ｖｉｓｏｒｙＣｏｍｍｉｔｔｅｅｏｎＩｍｍｕｎｉｚａｔｉｏｎＰｒａｃｔｉｃｅｓｆｏｒｕｓｅｏｆｈｅｒｐｅｓｚｏｓ ｔｅｒｖａｃｃｉｎｅｓ［Ｊ］．Ａｍ ＪＴｒａｎｓｐｌａｎｔ，２０１８，１８（３）：７５６７６２． ＤＯＩ：１０．１１１１／ａｊｔ．１４６８３． ［２７］ＬｅｖｉｎＭＪ．Ｕｓｅｏｆｖａｒｉｃｅｌｌａｖａｃｃｉｎｅｓｔｏｐｒｅｖｅｎｔｈｅｒｐｅｓｚｏｓｔｅｒｉｎｏｌ ｄｅｒｉｎｄｉｖｉｄｕａｌｓ［Ｊ］．ＡｒｃｈＶｉｒｏｌ，２００１，１７（１７）：１５１１６０．ＤＯＩ： １０．１００７／９７８３７０９１６２５９０＿１６． ［２８］ＳｐｅｒｂｅｒＳＪ，ＳｍｉｔｈＢＶ，ＨａｙｄｅｎＦＧ．Ｓｅｒｏｌｏｇｉｃｒｅｓｐｏｎｓｅａｎｄｒｅａｃ ｔｏｇｅｎｉｃｉｔｙｔｏｂｏｏｓｔｅｒｉｍｍｕｎｉｚａｔｉｏｎｏｆｈｅａｌｔｈｙｓｅｒｏｐｏｓｉｔｉｖｅａｄｕｌｔｓ ｗｉｔｈｌｉｖｅｏｒｉｎａｃｔｉｖａｔｅｄｖａｒｉｃｅｌｌａｖａｃｃｉｎｅ［Ｊ］．ＡｎｔｉｖｉｒａｌＲｅｓ， １９９２，１７（３）：２１３２２２．ＤＯＩ：１０．１０１６／０１６６３５４２（９２）９００４２４． ［２９］ＭａｓａｈｉｒｏＫ，ＳｏｎｇＷｏｎｇＫ，ＹｏｉｃｈｉＴ．Ｖａｒｉｃｅｌｌａｖａｃｃｉｎｅｉｎｒｅｃｉｐｉ ｅｎｔｓｏｆｈｅｍａｔｏｐｏｉｅｔｉｃｃｅｌｌｔｒａｎｓｐｌａｎｔｓ［Ｊ］．ＮＥｎｇｌＪＭｅｄ，２００２， ３４７（２０）：１６２４１６２５．ＤＯＩ：１０．１０５６／ＮＥＪＭ２００２１１１４３４７２０１７． ［３０］ＭｕｌｌａｎｅＫＭ，ＷｉｎｓｔｏｎＤＪ，ＷｅｒｔｈｅｉｍＭＳ，ｅｔａｌ．Ｓａｆｅｔｙａｎｄｉｍｍｕ ｎｏｇｅｎｉｃｉｔｙｏｆｈｅａｔｔｒｅａｔｅｄｚｏｓｔｅｒｖａｃｃｉｎｅ（ＺＶＨＴ）ｉｎｉｍｍｕｎｏｃｏｍ ｐｒｏｍｉｓｅｄａｄｕｌｔｓ［Ｊ］．ＪＩｎｆｅｃｔＤｉｓ，２０１３，２０８（９）：１３７５１３８５． ＤＯＩ：１０．１０９３／ｉｎｆｄｉｓ／ｊｉｔ３４４． ［３１］ＷｉｎｓｔｏｎＤＪ，ＭｕｌｌａｎｅＫＭ，ＣｏｒｎｅｌｙＯＡ，ｅｔａｌ．Ｉｎａｃｔｉｖａｔｅｄｖａｒｉｃｅｌ ｌａｚｏｓｔｅｒｖａｃｃｉｎｅｉｎａｕｔｏｌｏｇｏｕｓｈａｅｍｏｐｏｉｅｔｉｃｓｔｅｍｃｅｌｌｔｒａｎｓｐｌａｎｔ ｒｅｃｉｐｉｅｎｔｓ：ａｎｉｎｔｅｒｎａｔｉｏｎａｌ，ｍｕｌｔｉｃｅｎｔｒｅ，ｒａｎｄｏｍｉｓｅｄ，ｄｏｕｂｌｅ ｂｌｉｎｄ，ｐｌａｃｅｂｏｃｏｎｔｒｏｌｌｅｄｔｒｉａｌ［Ｊ］．Ｌａｎｃｅｔ，２０１８，３９１（１０１３５）： ２１１６２１２７．ＤＯＩ：１０．１０１６／Ｓ０１４０６７３６（１８）３０６３１７． ［３２］ＳｃｈｍｉｄｔＣｈａｎａｓｉｔＪ，ＳａｕｅｒｂｒｅｉＡ．Ｅｖｏｌｕｔｉｏｎａｎｄｗｏｒｌｄｗｉｄｅｄｉｓｔｒｉ ｂｕｔｉｏｎｏｆｖａｒｉｃｅｌｌａｚｏｓｔｅｒｖｉｒｕｓｃｌａｄｅｓ［Ｊ］．ＩｎｆｅｃｔＧｅｎｅｔＥｖｏｌ， ２０１１，１１（１）：１１０．ＤＯＩ：１０．１０１６／ｊ．ｍｅｅｇｉｄ．２０１０．０８．０１４． ［３３］ＡｄｒｉａｎａＷ，ＺｈａｎｇＪＨ，ＯｘｍａｎＭＮ，ｅｔａｌ．Ｖａｒｉｃｅｌｌａｚｏｓｔｅｒｖｉｒｕｓ ｓｐｅｃｉｆｉｃｉｍｍｕｎｅｒｅｓｐｏｎｓｅｓｔｏｈｅｒｐｅｓｚｏｓｔｅｒｉｎｅｌｄｅｒｌｙｐａｒｔｉｃｉｐａｎｔｓ ｉｎａｔｒｉａｌｏｆａｃｌｉｎｉｃａｌｌｙｅｆｆｅｃｔｉｖｅｚｏｓｔｅｒｖａｃｃｉｎｅ［Ｊ］．ＪＩｎｆｅｃｔＤｉｓ， ２００９，２００（７）：１０６８１０７７．ＤＯＩ：１０．１０８６／６０５６１１． （收稿日期：２０１９０５１５） （修回日期：２０１９０７３１） （本文编辑：李清茹） （上接第 １４０８页） ［２７］ ＳｕｓｓｅｒＥ，ＮｅｕｇｅｂａｕｅｒＲ，ＨｏｅｋＨＷ，ｅｔａｌ．Ｓｃｈｉｚｏｐｈｒｅｎｉａａｆｔｅｒ ｐｒｅｎａｔａｌｆａｍｉｎｅ．Ｆｕｒｔｈｅｒｅｖｉｄｅｎｃｅ［Ｊ］．ＡｒｃｈＧｅｎＰｓｙｃｈｉａｔｒｙ， １９９６，５３（１）：２５３１．ＤＯＩ：１０．１００１／ａｒｃｈｐｓｙｃ．１９９６．０１８３００１００ ２７００５． ［２８］ＳｔＣｌａｉｒＤ，ＸｕＭ，ＷａｎｇＰ，ｅｔａｌ．Ｒａｔｅｓｏｆａｄｕｌｔｓｃｈｉｚｏｐｈｒｅｎｉａ ｆｏｌｌｏｗｉｎｇｐｒｅｎａｔａｌｅｘｐｏｓｕｒｅｔｏｔｈｅＣｈｉｎｅｓｅｆａｍｉｎｅｏｆ１９５９－１９６１ ［Ｊ］．ＪＡＭＡ，２００５，２９４（５）：５５７５６２．ＤＯＩ：１０．１００１／ｊａｍａ．２９４． ５．５５７． ［２９］ＸｕＭＱ，ＳｕｎＷＳ，ＬｉｕＢＸ，ｅｔａｌ．Ｐｒｅｎａｔａｌｍａｌｎｕｔｒｉｔｉｏｎａｎｄａｄｕｌｔ ｓｃｈｉｚｏｐｈｒｅｎｉａ：ｆｕｒｔｈｅｒｅｖｉｄｅｎｃｅｆｒｏｍ ｔｈｅ１９５９－１９６１Ｃｈｉｎｅｓｅ ｆａｍｉｎｅ［Ｊ］．ＳｃｈｉｚｏｐｈｒＢｕｌｌ，２００９，３５（３）：５６８５７６．ＤＯＩ：１０． １０９３／ｓｃｈｂｕｌ／ｓｂｎ１６８． ［３０］ＳｏｎｇＳ，ＷａｎｇＷ，ＨｕＰ．Ｆａｍｉｎｅ，ｄｅａｔｈ，ａｎｄｍａｄｎｅｓｓ：ｓｃｈｉｚｏ ｐｈｒｅｎｉａｉｎｅａｒｌｙａｄｕｌｔｈｏｏｄａｆｔｅｒｐｒｅｎａｔａｌｅｘｐｏｓｕｒｅｔｏｔｈｅＣｈｉｎｅｓｅ ＧｒｅａｔＬｅａｐＦｏｒｗａｒｄＦａｍｉｎｅ［Ｊ］．ＳｏｃＳｃｉＭｅｄ，２００９，６８（７）： １３１５１３２１．ＤＯＩ：１０．１０１６／ｊ．ｓｏｃｓｃｉｍｅｄ．２００９．０１．０２７． ［３１］ＨｅＰ，ＣｈｅｎＧ，ＧｕｏＣ，ｅｔａｌ．Ｌｏｎｇｔｅｒｍｅｆｆｅｃｔｏｆｐｒｅｎａｔａｌｅｘｐｏ ｓｕｒｅｔｏｍａｌｎｕｔｒｉｔｉｏｎｏｎｒｉｓｋｏｆｓｃｈｉｚｏｐｈｒｅｎｉａｉｎａｄｕｌｔｈｏｏｄ：Ｅｖｉｄｅｎｃｅ ｆｒｏｍｔｈｅＣｈｉｎｅｓｅｆａｍｉｎｅｏｆ１９５９－１９６１［Ｊ］．ＥｕｒＰｓｙｃｈｉａｔｒｙ， ２０１８，５１：４２４７．ＤＯＩ：１０．１０１６／ｊ．ｅｕｒｐｓｙ．２０１８．０１．００３． ［３２］ＨｕａｎｇＣ，ＰｈｉｌｌｉｐｓＭＲ，ＺｈａｎｇＹ，ｅｔａｌ．Ｍａｌｎｕｔｒｉｔｉｏｎｉｎｅａｒｌｙｌｉｆｅ ａｎｄａｄｕｌｔｍｅｎｔａｌｈｅａｌｔｈ：ｅｖｉｄｅｎｃｅｆｒｏｍａｎａｔｕｒａｌｅｘｐｅｒｉｍｅｎｔ［Ｊ］． ＳｏｃＳｃｉＭｅｄ，２０１３，９７（４）：２５９２６６．ＤＯＩ：１０．１０１６／ｊ．ｓｏｃｓ ｃｉｍｅｄ．２０１２．０９．０５１． ［３３］Ｗａｎｇ，Ｃ，ＺｈａｎｇＹ．Ｓｃｈｉｚｏｐｈｒｅｎｉａｉｎｍｉｄａｄｕｌｔｈｏｏｄａｆｔｅｒｐｒｅｎａｔａｌ ｅｘｐｏｓｕｒｅｔｏｔｈｅＣｈｉｎｅｓｅＦａｍｉｎｅｏｆ１９５９－１９６１［Ｊ］．Ｓｃｈｉｚｏｐｈｒ Ｒｅｓ，２０１７，１８４：２１２５．ＤＯＩ：１０．１０１６／ｊ．ｓｃｈｒｅｓ．２０１６．１１．０３０ ［３４］ＳｔｅｉｎＺ，ＳｕｓｓｅｒＭ，ＳａｅｎｇｅｒＧ．Ｆａｍｉｎｅａｎｄｈｕｍａｎｄｅｖｅｌｏｐｍｅｎｔ： ｔｈｅＤｕｔｃｈｈｕｎｇｅｒｗｉｎｔｅｒｏｆ１９４４１９４５［Ｍ］．ＮｅｗＹｏｒｋ：Ｏｘｆｏｒｄ ＵｎｉｖｅｒｓｉｔｙＰｒｅｓｓ，１９７５． ［３５］徐家伟．精神分裂症关联分析与母亲孕期饥荒致子代易感精 神分裂症机制研究 ［Ｄ］．上海：复旦大学，２０１３． ＸｕＪＷ．Ａｓｓｏｃｉａｔｉｏｎｓｔｕｄｙｏｆｓｃｈｉｚｏｐｈｒｅｎｉａａｎｄｐｒｅｎａｔａｌｆａｍｉｎｅｒｅ ｐｒｏｇｒａｍｅｄｐｏｓｔｎａｔａｌｇｅｎｅｅｘｐｒｅｓｓｉｏｎｉｎｍａｍｍａｌ’ｓｂｒａｉｎ［Ｄ］． Ｓｈａｎｇｈａｉ：ＦｕＤａｎＵｎｉｖｅｒｓｉｔｙ，２０１３． ［３６］ＦｒａｎｋｅＫ，ＧａｓｅｒＣ，ＲｏｓｅｂｏｏｍＴＪ．Ｐｒｅｍａｔｕｒｅｂｒａｉｎａｇｉｎｇｉｎｈｕ ｍａｎｓｅｘｐｏｓｅｄｔｏｍａｔｅｒｎａｌｎｕｔｒｉｅｎｔｒｅｓｔｒｉｃｔｉｏｎｄｕｒｉｎｇｅａｒｌｙｇｅｓｔａｔｉｏｎ ［Ｊ］．Ｎｅｕｒｏｉｍａｇｅ，２０１８，１７３：４６０４７１．ＤＯＩ：１０．１０１６／ｊ．ｎｅｕｒｏ ｉｍａｇｅ．２０１７．１０．０４７． ［３７］ＫｈａｓｈａｎＡＳ，ＡｂｅｌＫＭ，ＭｃＮａｍｅｅＲ，ｅｔａｌ．Ｈｉｇｈｅｒｒｉｓｋｏｆｏｆｆ ｓｐｒｉｎｇｓｃｈｉｚｏｐｈｒｅｎｉａｆｏｌｌｏｗｉｎｇａｎｔｅｎａｔａｌｍａｔｅｒｎａｌｅｘｐｏｓｕｒｅｔｏｓｅ ｖｅｒｅａｄｖｅｒｓｅｌｉｆｅｅｖｅｎｔｓ［Ｊ］．ＡｒｃｈＧｅｎＰｓｙｃｈｉａｔｒｙ，２００８，６５（２）： １４６１５２．ＤＯＩ：１０．１００１／ａｒｃｈｇｅｎｐｓｙｃｈｉａｔｒｙ．２００７．２０． ［３８］ＵｄａｇａｗａＪ，ＨｉｎｏＫ．Ｉｍｐａｃｔｏｆｍａｔｅｒｎａｌｓｔｒｅｓｓｉｎｐｒｅｇｎａｎｃｙｏｎ ｂｒａｉｎｆｕｎｃｔｉｏｎｏｆｔｈｅｏｆｆｓｐｒｉｎｇ［Ｊ］．ＮｉｈｏｎＥｉｓｅｉｇａｋｕＺａｓｓｈｉ， ２０１６，７１（３）：１８８１９４．ＤＯＩ：１０．１２６５／ｊｊｈ．７１．１８８． ［３９］ＣａｏＬｅｉＬ，ＥｌｇｂｅｉｌｉＧ，ＭａｓｓａｒｔＲ，ｅｔａｌ．Ｐｒｅｇｎａｎｔｗｏｍｅｎ＇ｓｃｏｇｎｉ ｔｉｖｅａｐｐｒａｉｓａｌｏｆａｎａｔｕｒａｌｄｉｓａｓｔｅｒａｆｆｅｃｔｓＤＮＡｍｅｔｈｙｌａｔｉｏｎｉｎｔｈｅｉｒ ｃｈｉｌｄｒｅｎ１３ｙｅａｒｓｌａｔｅｒ：ＰｒｏｊｅｃｔＩｃｅＳｔｏｒｍ［Ｊ］．ＴｒａｎｓｌＰｓｙｃｈｉａｔｒｙ， ２０１５，５：ｅ５１５．ＤＯＩ：１０．１０３８／ｔｐ．２０１５．１３． （收稿日期：２０１９０６１５） （修回日期：２０１９０９１２） （本文编辑：王雪萍） ·１４１４· 中华疾病控制杂志 ２０１９年 １１月第 ２３卷第 １１期 ＣｈｉｎＪＤｉｓＣｏｎｔｒｏｌＰｒｅｖ ２０１９Ｎｏｖ；２３（１１）