Autacoid Drugs ·Autacoids(自体活性物质)are biological factors made in the body that act like"local hormones", have a brief duration,act near the site of synthesis (paracrine),and are not blood borne. Autacoids are regulating molecules metabolized locally. These factors can have many different biological actions. Major autacoids ·Arachidonic acid metabolites(花生四烯酸) including:prostaglandins(前列腺素)， thromboxanes(血栓素)，leukotrienes(白三烯) ·5-hydroxytryptamine,5-HT(五羟色胺)，also named serotonin(血清素) ·Bradykinin(缓激肽) ·Endothelin(内皮素) Substance P(P物质)Autacoid Drugs • Autacoids (自体活性物质) are biological factors made in the body that act like “local hormones”, have a brief duration, act near the site of synthesis (paracrine), and are not blood borne. • Autacoids are regulating molecules metabolized locally. • These factors can have many different biological actions. Major autacoids • Arachidonic acid metabolites (花生四烯酸) including：prostaglandins (前列腺素), thromboxanes (血栓素), leukotrienes (白三烯) • 5-hydroxytryptamine, 5-HT (五羟色胺）,also named serotonin (血清素) • Bradykinin (缓激肽) • Endothelin (内皮素) • Substance P (P 物质)