Synthesis of Eicosanoids(二十烷类) 777777 4… Phospholipase Ae Arachidonic acid 5-Lpox闪ygenase Prostaglandin G2 5-HPETE Prostaglandin H2 Leukotriene A Prostaglandin l2 Prosta Prostaglandin F2o Leukotriene Da Leukotriene E Arachidonic Acid (AA) (5.8.11.14 eicosatetraenoic acid) COOH 入CH3 .20 carbon,unsaturated fatty acid .Gives rise to PGs,thromboxanes and leukotrienes .Phospholipase A2(PLA2)and phospholipase C(PLC)generate AA from phospholipids and diacylglycerols .Fatty acid cyclooxygenases(COX-1 and COX-2)initiate the biosynthesis of the PGs and TXs(prostanoids) .Various lipoxygenases give rise to leukotrienes and lipoxins (inhib.of lipoxygenase are potential anti-asthmatic drugs)Synthesis of Eicosanoids (二十烷类)