r d(cooh]- aC(OH)3I P 3[C(OD2[OH] [C(OH),] K, [[HA k [A-] k,ks.[COOH JOHJHA] [A-] K [H][4] HA R kk3 P kK COOH TOHH=KoICOOHIOHH TI HA R,=ko[COOH OHJLH[ ( ) ][ ] [ ] [ ( ) ] 3 2 3 k C OH OH dt d C OH dt d COOH Rp + + = − = = [ ] [ ][ ] [ ( ) ] 2 1 2 − + = A COOH HA k k C OH [ } [ ][ ] HA H A K HA + − = [ ][ ][ ] [ ][ ][ ] 0 2 1 3 + + = • COOH OH H = k COOH OH H k K k k R H A p [ ][ ][ ] 0 + Rp = k COOH OH H [ ] [ ][ ][ ] 2 1 3 − = • A COOH OH HA k k k Rp