河北医科大学药学院 Monoterpenoids and Quinone in Algae Monoterpenoids in Red Algae hornemamnil,was regonized as am amti-cancer lead by NCl. a人m上总靴 Sesquiterpenoids in Red Algae Sesquiterpenoids in Red Algae 持持线君Lo:2水价来类复的m多 持持交夫经君酒Lamd:26科才来表量的w字 0以6 HO 公天 o人人 C聚乙酰类代谢物 Phlorotannins derived from marine algae rtog 天然药化教研室史清文教授 10 河北医科大学药学院 天然药化教研室史清文教授 10 Maryssa G. A. Mann, et al: J. Nat. Prod., 2007, 70 (4), 596 -599. Catherine E. Sansom, et al. J. Nat. Prod. 2007, 70 : 2042-2044. Monoterpenoids and Quinone in Algae CH3 Br Br CH3 CHO 1 CH3 Cl CH3 CHO 2 Cl South African marine red alga Brown Alga Perithalia capillaris Cl Br B Cl r Cl Halomon Cl Cl Br Cl Cl Br Cl Cl Cl Br Halogenated monoterpene is very popular in red algae. Especially Cl and Br often occur in monoterpenoids of red algae. Halomon, which was isolated from Portieria hornemannii, was regonized as an anti-cancer lead by NCI. Monoterpenoids in Red Algae Sesquiterpenoids in Red Algae • 主要来源于凹顶藻属Laurencia：26种骨架类型的400多 种萜类化合物。 OAc 1 HO Br CHBr2 OH 2 1 来源于澳大利亚Laurencia rigida,具有抗附着活性。 2 来源于未确定的Laurencia sp, 对乳腺癌和克隆癌有显著的活性。 J. Nat. Prod. 2001, 64, 690-791. Sesquiterpenoids in Red Algae • 主要来源于凹顶藻属Laurencia：26种骨架类型的400多 种萜类化合物。 Elatol Obtusol Laurencia dendroidea Laurencia dendroidea Red Seaweed 红藻 C15聚乙酰类代谢物 C15聚乙酰类衍生物是红藻的一大类代谢产物，广泛存在 于凹顶藻属的多种红藻中，通常以链状或环氧形式存在。 1 来源于土耳其海域红藻，具12元环醚结构。 2 来源于希腊海域红藻，具很强的杀蚂蚁活性。 Phytochemistry 2002, 59, 111-116 1 2 O O Cl Br Br H H O Br Cl AcO Cl 1 2 3 4 5 7 6 8 9 10 11 12 13 14 15 1 2 3 4 5 7 6 8 9 10 11 12 13 14 15 Phlorotannins derived from marine algae Brown algae have been recognized as a rich source of Phlorotannins exhibited various beneficial bioactivities such as anti-oxidant, anti-cancer, anti-diabetic, anti-HIV, anti-allergic properties. 海藻多酚