傅更洋,等组织工程化神经修复周国神经创伤的应用 Q元wmom 43] Martin GR Isolation of a pluripotent cell line from early mouse [55] Tannemaat MR, Eggers R, Hendriks W,et al. Differential embryos cultured in medium conditioned by teratocarcinoma effects of lentiviral vector-mediated overexpression of nerve em cells. Proc Natl Acad SciU SA. 1981: 78(12) growth factor and glial cell line-derived neurotrophic factor on regenerating sensory and motor axons in the transected [44]Cui L, Jiang J, Wei L, et al. Transplantation of embryonic stem peripheral nerve. Eur J Neurosci. 2008: 28(8): 1467-1479 ells improves nerve repair and functional recovery after 56] Trupp M, Ryden M, Jornvall H, et al. Peripheral expression severe sciatic nerve axotomy in rats. Stem Cells. and biological activities of GDNF, a new neurotrophic factor 2008:26(5):1356-1365 for avian and mammalian peripheral neurons. J Cell Biol [45 Liu Q, Spusta SC, Mi R, et al. Human neural crest stem cells 1995130(1):137148. derived from human ESCs and induced pluripotent stem cells: [57 Santosa KB, Jesuraj NJ, Viader A, et al. Nerve allografts schwann cells. Stem Cells Transl Med. 2012: 1 (4): 266-278 glial-cell-line-derived neurotrophic factor. Muscle Nerve [46]Nussbaum J, Minami E, Laflamme MA, et al. Transplantation 201347(2)213-223 of undifferentiated murine embryonic stem cells in the heart 58 Tannemaat MR, Eggers R, Hendriks WT, et al. Differenti teratoma formation and immune response. FASEB J. effects of lentiviral vector-mediated overexpression of nerve regenerating sensory and motor axons in the transected Biomaterials for Neural Tissue Regeneration. Recent peripheral nerve. Eur J Neurosci. 2008; 28(8): 1467-1479 on Biomedical Engineering. 2013: 6(1): 29-39 [59 Blits B, Carlstedt TP, Rutenberg MJ, et al. Rescue and [48]Tran PA, Zhang L, Webster TJ. Carbon nanofibers and sprouting of motoneurons following ventral root avulsion and arbon nanotubes in regenerative reimplantation combined with intraspinal adeno-t Rev.2009;61(12):1097-1114 viral vector-mediated expression of glial cell line-deriver [49Malarkey EB, Fisher KA, Bekyarova E, et al. Conductive neurotrophic factor or brain-derived neurotrophic factor Exp single-walled carbon nanotube substrates modulate neuronal Neuro2004;189(2)303-316. growth. Nano Lett. 2009: 9(1): 264-268 [60] Shakhbazau A, Kawasoe J, Hoyng SA, et al. Early [50 Jin GZ, Kim M, Shin US, et al. Neurite outgrowth of dorsal root regenerative effects of NGF-transduced Schwann cells in ganglia neurons is enhanced on aligned nanofibrous peripheral nerve repair. Mol Cell Neurosci biopolymer scaffold with carbon nanotube coating. Neurosci 201250(1):103112 Lett2011501(1):10-14 61]张伟李明傅强.静电纺丝纤维支架在神经组织工程中的应用 [51] Olakowska E, Woszczycka-Korczynska I 进展J]中华外科杂志,201048(20:1584-1587 ledrzejowska-Szypulka H, et al. Application of nanotubes and [62] Rochkind S, Geuna S, Shainberg A Chapter nanofibres in nerve repair. A review. Folia Neuropathol Phototherapy in peripheral nerve injury effects on muscle 201048(4)231-237 on and nerve regeneration. Int Rev Neu 52]向宁王光林以导电性纳米碳管为支架的组织工程神经研究进 2008745464 展J]中国修复重建外科杂志,201125(11):1389-1392 [63] Panetsos F, Avendano C, Negredo P, et al. Neural prostheses [53] Wong LF, Goodhead L, Prat C, et al. Lentivirus-mediated gene and histological evaluation of central transfer to the central nervous system: therapeutic and nervous system alterations due to long-term implants of sieve research applications. Hum Gene Ther. 2006; 17(1): 1-9 electrodes to peripheral nerves in cats. IEEE Trans Neural 4] Hendriks WT, Eggers R, Carlstedt TP, et al. Lentiviral Syst Rehabil Eng. 2008: 16(3): 223-232 vector-mediated reporter gene expression in avulsed spinal ventral root is short-term, but is prolonged using an immune stealth"transgene Restor Neurol Neurosci 200725(56):585-599 7340 Po.Box1200,Shenyang110004www.crter.org o1994-2013ChinaAcademicJournalElectronicPublishingHouse.Allrightsreservedhttp:/www.cnki.net傅重洋，等. 组织工程化神经修复周围神经创伤的应用 7340 P.O. Box 1200, Shenyang 110004 www.CRTER.org www.CRTER.org [43] Martin GR. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci U S A. 1981;78(12): 7634-7638. [44] Cui L, Jiang J, Wei L,et al. Transplantation of embryonic stem cells improves nerve repair and functional recovery after severe sciatic nerve axotomy in rats. Stem Cells. 2008;26(5):1356-1365. [45] Liu Q, Spusta SC, Mi R,et al. Human neural crest stem cells derived from human ESCs and induced pluripotent stem cells: induction, maintenance, and differentiation into functional schwann cells. Stem Cells Transl Med. 2012;1(4):266-278. [46] Nussbaum J, Minami E, Laflamme MA,et al. Transplantation of undifferentiated murine embryonic stem cells in the heart: teratoma formation and immune response. FASEB J. 2007;21(7):1345-1357. [47] Nguyen TY, Liu H. A Review of Current Advances in Biomaterials for Neural Tissue Regeneration. Recent Patents on Biomedical Engineering.2013;6(1):29-39. [48] Tran PA, Zhang L, Webster TJ. Carbon nanofibers and carbon nanotubes in regenerative medicine. Adv Drug Deliv Rev. 2009;61(12):1097-1114. [49] Malarkey EB, Fisher KA, Bekyarova E,et al. Conductive single-walled carbon nanotube substrates modulate neuronal growth. Nano Lett. 2009;9(1):264-268. [50] Jin GZ, Kim M, Shin US,et al. Neurite outgrowth of dorsal root ganglia neurons is enhanced on aligned nanofibrous biopolymer scaffold with carbon nanotube coating. Neurosci Lett. 2011;501(1):10-14. [51] Olakowska E, Woszczycka-Korczyńska I, Jędrzejowska-Szypułka H,et al. Application of nanotubes and nanofibres in nerve repair. A review. Folia Neuropathol. 2010;48(4):231-237. [52] 向宁,王光林.以导电性纳米碳管为支架的组织工程神经研究进 展[J]. 中国修复重建外科杂志, 2011,25(11):1389-1392. [53] Wong LF, Goodhead L, Prat C,et al. Lentivirus-mediated gene transfer to the central nervous system: therapeutic and research applications. Hum Gene Ther. 2006;17(1):1-9. [54] Hendriks WT, Eggers R, Carlstedt TP,et al. Lentiviral vector-mediated reporter gene expression in avulsed spinal ventral root is short-term, but is prolonged using an immune "stealth" transgene. Restor Neurol Neurosci. 2007;25(5-6):585-599. [55] Tannemaat MR, Eggers R, Hendriks WT,et al. 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