General properties of Macrolides 3 Antimicrobial spectrum(广谱): G+ organisms: cocci: streptococcus pyogenes, hemolytic streptococcus and streptococcus pneumoniae(化脓性、溶血性和肺炎链球菌, staphylococcus( produceβ- actamase or MrSA耐甲氧西林的金葡菌) baci: Corynebacterium diphtheria(白喉杆菌, bacillus anthraci(炭疽杆菌 clostridium tetani(破伤风杆菌) Gorganisms CocCI: meningococcus(脑膜炎奈瑟菌),N. gonorrhoeae(淋病奈瑟菌) bacilli: legione lla pneumophila(军团菌), bordetella pertussis(百日咳杆菌), haemophilus influenzae(流感嗜血杆菌)(对大肠埃希菌、变形杆菌无效 Other: anaerobe(厌氧球菌 mycoplasma pneumoniae(肺炎支原体) - chlamydia(衣原体 rickettsia(立克次体) - spirochetes(螺旋体)3. Antimicrobial spectrum （广谱）： G+ organisms: - cocci: streptococcus pyogenes, hemolytic streptococcus and streptococcus pneumoniae (化脓性、溶血性和肺炎链球菌), staphylococcus (produce β- lactamase or MRSA耐甲氧西林的金葡菌) - bacilli: Corynebacterium diphtheria (白喉杆菌), bacillus anthraci (炭疽杆菌) ， clostridium tetani (破伤风杆菌) G- organisms: - cocci: meningococcus (脑膜炎奈瑟菌)， N. gonorrhoeae (淋病奈瑟菌) - bacilli:legionella pneumophila (军团菌), bordertella pertussis(百日咳杆菌), haemophilus influenzae (流感嗜血杆菌) (对大肠埃希菌、变形杆菌无效) Other： - anaerobe (厌氧球菌） - mycoplasma pneumoniae (肺炎支原体) - chlamydia (衣原体) - rickettsia (立克次体) - spirochetes (螺旋体) General properties of Macrolides