Nucleophiles The nucleophiles mostly are anions. HO:HS:: :N三C: etc. Not all nucleophiles are anions.Many are neutral. HOH CHgOH NH3 for example All nucleophiles,however,are Lewis bases.College of Science Nucleophiles The nucleophiles mostly are anions. – : : N C .. .. HS: .. – .. HO: – .. .. CH 3 O: – etc. Not all nucleophiles are anions. Many are neutral. .. .. HOH CH 3OH.. .. NH 3 : for example All nucleophiles, however, are Lewis bases