Journal of Natural Products N■NB■ND■S■S/NM■S·■5/NM■ ure 4. 11d2012.75.311-35Figure 4. Sources of small molecule NCEs by source/year. Table 1. New Chemical Entities and Medical Indications by Source of Compound 01/01/1981 to 12/31/2010a indication total B N NB ND S S/NM S* S*/NM V COPD 4 1 3 analgesic 17 1 11 3 2 anesthetic 5 5 anti-Alzheimer 4 1 3 anti-Parkinsonian 12 2 1 5 4 antiallergic 17 1 1 4 11 antianginal 5 5 antiarrhythmic 17 1 14 2 antiarthritic 17 6 1 1 3 6 antiasthmatic 14 1 3 2 6 2 antibacterial 118 10 67 26 1 14 anticancer 128 24 11 1 32 20 16 11 8 5 anticoagulant 19 5 13 1 antidepressant 23 7 14 2 antidiabetic 37 18 1 5 4 8 1 antiemetic 11 1 2 8 antiepileptic 15 2 9 2 2 antifungal 29 1 3 22 3 antiglaucoma 14 5 5 1 3 antihistamine 13 13 antihyperprolactinemia 4 4 antihypertensive 79 2 28 14 2 33 anti-inflammatory 51 1 13 37 antimigraine 10 2 1 7 antiobesity 4 1 3 antiparasitic 14 2 5 4 2 1 antipsoriatic 9 3 1 3 1 1 antipsychotic 10 3 5 2 antithrombotic 29 13 1 5 2 6 2 antiulcer 34 1 1 12 20 antiviral 110 14 4 9 2 23 10 48 anxiolytic 10 8 2 benign prostatic hypertrophy 4 1 1 1 1 Journal of Natural Products Review 314 dx.doi.org/10.1021/np200906s | J. Nat. Prod. 2012, 75, 311−335