、围绕课题需求,开展信息检索 1.根据检索需求,选择检索工具:列出所选数据库(3种) 2.分析课题,确定检索词和检索语句:编写各种数据库的检索式 3.列出所选数据库检索获得的记录数、各摘录3条相关文献题录 数据库1: PubMed &a*: (Hypoxia-Inducible Factor" [TIAB] OR"HIF"[])AND(Neoplasm Metastasis"[Mesh] OR"Neoplasm Invasiveness"[Mesh])AND ("2008/01/01"[PDAT]:"2008/12/3I"[PDAT]) 检索记录数:63 主要相关文献(3条题录) 1. Du R HIF1 alpha induces the recruitment of bone marrow-deri ved vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell. 2008;13(3):206-20 2. Rankin EB. The role of hypoxia-inducible factors in tumori genesis. Cell Death Differ. 2008: 15(4): 678-85 3. Gort EH Hypoxic regulation of metastasis via hypoxia-inducible factors Curr Mol Med.2008;8(1):60-7. 数据库2: Web of science 检索式:标题=( HIF OR hypoxia- induc*)AND标题=( metastasis OR migration OR inas米)AND主题=( tumor OR neoplasm OR cancer OR carcinoma) 入库时间=2008.数据库=SCI- EXPANDED 检索记录数:16 主要相关文献(3条题录) 1. Wu H Resveratrol inhibits hypoxia-induced metastasis potential enhancement by restricting hypoxia-induced factor-1 alpha expression in colon carcinoma cells. Biomed Pharmacother. 2008: 62(9): 613-621 2. Helczynska K Hypoxia-inducible factor-2alpha correlates to distant recurrence and poor outcome in invasive breast cancer. Cancer Res. 2008:68(22):9212-9220. 3. Yang MH. Direct regulation of TWIST by HIF-lalpha promotes metastasis Nat Cell Biol.2008;10(3):295-305 2/8