Lecture 7: Hydrogel Biomaterials: Structure and Physical Chemistry Last Day: programmed/regulated/multifactor controlled release for drug delivery and tissue engineering

Lecture 5: Controlled Release Devices Last time: Using enzyme substrate and cytokine peptides to engineer biological recognition of synthetic polymers Today: principles of controlled release devices based on degradable polymers Synthesis of controlled release devices Theory of polymer-based controlled release

Biological recognition in vivo Engineering biological recognition of biomaterials: adhesion/migration peptides Engineering biological recognition of biomaterials: enzymatic recognition and cytokine Reading S.E. Sakiyama-Elbert and J.A. Hubbell, Functional Biomaterials: Design of Novel

山西师范大学：《生物无机化学》课程教学大纲（材料化学专业）

2．化学控制途径 (a) 层层溶蚀装置药物与溶蚀性或可溶性聚合物基材组成一体

1． 透皮 药物通过皮肤进入系统循环 传统制剂：油膏 新型：控制释放贴片

我们所指的“控制释放”是什么？ 控制： 1.输送速率 2.释放位置/作用点

1. 细胞培养 a. 为何采用细胞培养？

1． 细胞封囊化治疗糖尿病 糖尿病 Mellitus( Ⅰ型或只与胰岛素有关)：胰腺停止产生胰岛素，胰腺紊乱

高真空技术是表征材料表面成份的重要方法，但它不能提供有关表面结构或水合条件下化学性质等方面的信息。 用于表征水基表面的方法是有限的。下面列举三种常用的方法：