Biodegradable solid polymeric Materials Today course overview and administrative details Intro to concepts covered Chemistry and physical chemistry of biodegradable polymeric solids Hand-outs course syllabus Course administrative details Readin Third-Generation Biomedical Materials. \LL Hench and j M. Polak. Science 295

Lecture 2: Molecular Design and Synthesis of Biomaterials I: Biodegradable Solid Polymeric Materials(continued) hemistry and physical chemistry of degrading polymeric solids for biomaterials Today Theory of polymer erosion Enzymatic degradation of synthetic biomaterials Designing degradable materials Reading

Molecular Principles of Biomaterials Spring 2003 Lecture 2: Molecular Design and Synthesis of Biomaterials I: Biodegradable Materials Chemistry of Biodegradable Materials Hydrolytically degraded biomaterials Common hydrolytically unstable linkages Ester

Lecture 5: Controlled Release Devices Last time: Using enzyme substrate and cytokine peptides to engineer biological recognition of synthetic polymers Today: principles of controlled release devices based on degradable polymers Synthesis of controlled release devices Theory of polymer-based controlled release

Lecture 7: Hydrogel Biomaterials: Structure and Physical Chemistry Last Day: programmed/regulated/multifactor controlled release for drug delivery and tissue engineering

Lecture 10: Bioengineering applications of hydrogels: Molecular Imprinting and Drug Delivery Last Day polyelectrolyte gels Polyelectrolyte complexes and multilayers Applications in bioengineering Theory of ionic gel swelling Toda Molecular imprinting

Lecture 8: Physical Hydrogels Last Day Overview of biomedical applications of hydrogels Structure of covalent hydrogels Thermodynamics of hydrogel swelling Today Bonding in physical hydrogels Structure and thermodynamics of block copolymer hydrog Reading

Brannon-Peppas theory of swelling in ionic hydrogels Original theory for elastic networks developed by Flory and Mehrer, refined for treatment of ionic hydrogels by Brannon-Peppas and Peppas Other theoretical treatments Derivation of ionic hydrogel swelling Model structure of the system

Molecular switches in the cell: fibronectin as a mechanical switch (vogel, 2002) Fibronectin is an adhesion protein secreted by cells and assembled into fibrils to support adhesion and migration Composed of\ of fibronectin repeats Fnl, Fnll, and Fnlll connected by short linkers of varying flexibility One particular Fnlll repeat, Fnlll10

molecular switches Proteins as motors in nanodevices Today. nano-and micro-particle drug carriers Reading D A Hammer and D.E. Discher, ' Synthetic cells- Self-assembling polymer membranes and bioadhesive colloids, Annu. Rev. Mater Res, 31, 387-404 (2001) Nano- and Micro-scale Drug Carriers and Detection Reagents Nano- to Micro-particle polymer-protein