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Definition Bacteremia: Bacteria invade into blood temporarily with flora <100 CFU/ml in blood XSepticemia or Sepsis: Pathogens (bacteria or fungi) invade into blood, proliferate greatly, and release endotoxin XToxemia: Endotoxin absorbed into blood with no bacteria
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Biological recognition in vivo Engineering biological recognition of biomaterials: adhesion/migration peptides Engineering biological recognition of biomaterials: enzymatic recognition and cytokine Reading S.E. Sakiyama-Elbert and J.A. Hubbell, Functional Biomaterials: Design of Novel
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Lecture 2: Molecular Design and Synthesis of Biomaterials I: Biodegradable Solid Polymeric Materials(continued) hemistry and physical chemistry of degrading polymeric solids for biomaterials Today Theory of polymer erosion Enzymatic degradation of synthetic biomaterials Designing degradable materials Reading
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Example: HIV-1 DNA vaccine delivered with boosters to elevate Ab titers2: Mechanical and electrical devices that can provide digitized release typically require larger devices and surgical implantation(e.g. Pharm. Res. 1, 237(1984); also have high cost
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Lecture 7: Hydrogel Biomaterials: Structure and Physical Chemistry Last Day: programmed/regulated/multifactor controlled release for drug delivery and tissue engineering
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Lecture 6: Biodegradable Polymers for Tissue Engineering Last time: enzymatic degradation of solid polymers Engineering biological recognition of polymers Toda Designing polymers for tissue engineering Reading
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Lecture 10: Bioengineering applications of hydrogels: Molecular Imprinting and Drug Delivery Last Day polyelectrolyte gels Polyelectrolyte complexes and multilayers Applications in bioengineering Theory of ionic gel swelling Toda Molecular imprinting
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Hydrogels in drug delivery Control of drug release kinetics by hydrogel structure6, Release from stable hydrogels is controlled by diffusion of solute through the network Diffusion is described by Fick,s second law
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Lecture 12: Organic templating of inorganic materials and bone biomimesis Last time interfacial biomineralization and biomimetic inorganic chemistry Today biological strategies for inorganic templating by organic materials Biomimetic
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Lecture 8: Physical Hydrogels Last Day Overview of biomedical applications of hydrogels Structure of covalent hydrogels Thermodynamics of hydrogel swelling Today Bonding in physical hydrogels Structure and thermodynamics of block copolymer hydrog Reading
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