General aspects – Remember definition: organisms frequently found on or within body of healthy individuals – Most are bacteria, but some are viruses, fungi, and protozoa

American Legion Convention in 1976 in Philadelphia hotel – Respiratory distress and fever – 200 affected – 34 died

General Aspects Ecology – Found throughout the environment Very simple nutritional requirements – Not usually in normal flora unless hospitalized or immunocompromised

Diversity of species Ecology – Found worldwide in soil, water, vegetation, and microbial flora of animals and humans – Some are always associated with disease

Comparison of Meningococcus and Gonococcus Pathobiology Similarities: – Both diploccocci – Share about 80% DNA – Neither makes exotoxin; both make endotoxin – Both are relatively good colonizers

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