Definition PEM is a kind of malnutrition caused by inadequate dietary intake or some diseases, occurs commonly in children under 3 years of age. Kwashiorkor Marasmus
Overview Definition of Accidental Trauma: Accident, Unexpected, Injuries Physically and/or Psychologically Causes: physical, chemical, and biological factors Main cause of mutilation and death in children globally
Definition Bacteremia: Bacteria invade into blood temporarily with flora <100 CFU/ml in blood XSepticemia or Sepsis: Pathogens (bacteria or fungi) invade into blood, proliferate greatly, and release endotoxin XToxemia: Endotoxin absorbed into blood with no bacteria
Biological recognition in vivo Engineering biological recognition of biomaterials: adhesion/migration peptides Engineering biological recognition of biomaterials: enzymatic recognition and cytokine Reading S.E. Sakiyama-Elbert and J.A. Hubbell, Functional Biomaterials: Design of Novel
Lecture 2: Molecular Design and Synthesis of Biomaterials I: Biodegradable Solid Polymeric Materials(continued) hemistry and physical chemistry of degrading polymeric solids for biomaterials Today Theory of polymer erosion Enzymatic degradation of synthetic biomaterials Designing degradable materials Reading
Example: HIV-1 DNA vaccine delivered with boosters to elevate Ab titers2: Mechanical and electrical devices that can provide digitized release typically require larger devices and surgical implantation(e.g. Pharm. Res. 1, 237(1984); also have high cost
Lecture 7: Hydrogel Biomaterials: Structure and Physical Chemistry Last Day: programmed/regulated/multifactor controlled release for drug delivery and tissue engineering
Lecture 6: Biodegradable Polymers for Tissue Engineering Last time: enzymatic degradation of solid polymers Engineering biological recognition of polymers Toda Designing polymers for tissue engineering Reading
