Much of the catalytic power of enzymes comes from their bringing sub- strates together in favorable orientations in enzyme-substrate (ES)com- plexes. The substrates are bound to a specific region of the enzyme called the active site. Most enzymes are highly selective in their binding

Announcement \Chapter 8 Enzymes: Basic Concepts and Kinetics\ in Lubert Stryer's \Biochemistry\ (Fourth Edition) will be used as my major lecture material, which is available for you to Xerox from your TAs. Chapter 8 in Lehninger's“ Principles of Biochemistry can be used as a reference

6.1 An introduction to antibiotics 6. 2 General strategies for the production of antibiotics 6.3 a brief history of penicillin production 6.4 Antibacterial mode of action of B-lactam antibiotics 6.5 Biosynthesis of penicillins and cephalosporins

一．氮循环及生物固氮 二．蛋白质降解 三．脱氨基作用 四．转氨基作用 五．联合脱氨作用 六．脱羧作用 七．氨的去路—尿素循环 八. 个别氨基酸代谢

一．氮循环及生物固氮 二．蛋白质降解 三．脱氨基作用 四．转氨基作用 五．联合脱氨作用 六．脱羧作用 七．氨的去路—尿素循环 八. 个别氨基酸代谢

1. Enzymes Are Powerful and Highly Specific Catalysts 2. Free Energy Is a Useful Thermodynamic Function for Understanding Enzymes －热力学

1. overview: site mitochondrion Outer membrane Inner membrane Intermembrane space Matrix Cristae (a) An electron micrograph of mitochondrion

第一节 概述 第二节 脂溶性维生素（维生素A、D、E、K） 第三节 水溶性维生素（维生素B、C）

I. 讨论先前的提议 II. 生物地球化学 a. 恐龙问题 b. 储存库和滞留时间 c. 例子：甲烷

1. Hemoglobin is a multisubunit allosteric protein that carries 02 in erythrocyte. 1.1 Hemoglobin is a well-studied and well-understood protein. 1.1.1 It was one of the first proteins to have its molecular mass accurately determined. 1.1.2 The first protein to be characterized by ultracentrifuge. 1.1.3 The first protein to be associated with a specific physiological function