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一、肢芽的形成 二、肢体近-远端轴线的生成 三、肢体A-P轴线的确定 四、肢体D-V轴线的确定 五、前肢和后肢发育机制有所不同 六、细胞凋亡与趾的形成 七、肢体的进化
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一、卵裂 Cleavage 二、原肠作用 Gastrulation
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一、神经管的形成 二、神经诱导作用 三、神经管的分化 四、神经元的分化 五、神经元的生长和凋亡
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I Systems Microbiology(13 Lectures 7hece∥ as a we∥}- stirred boc/ nem/ca/ reactor Introduction 2 Chemical kinetics, Equilibrium binding, cooperativity L3 Lambda phage L4 Stability analysis L5-6 Genetic switches
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Alternative views on gradient sensing Postma and van hastert. 'a diffusion-translocation model for gradient sensing by chemotactic cells Biophys.J.81,1314(2001) Levchenko and Iglesias. Models of eukaryotic gradient sensing: applications to chemotaxis of amoeba and neutrophils
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Review Turing-Gierer-Meinhardt models Local excitation, global inhibition 22r+hq
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Wrapping up E coli chemotaxis (L7& L8) Main points of last 2 lectures L7: Biological background what is the function of the individual molecules L8: modeling of all possible chemotactic reactions why doesn't this model reproduce experimentally observed perfect adaptation
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L14: 14 Lectures past and 1 1 to go Part 'The cell as a well-stirred bioreactor topICs Lambda phage lysis-lysogeny switch Synthetic genetic switch Switches as memory storage Chemotaxis: perfect adaptation or not? Synthetic genetic oscillators
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Mathematical basis of stability analysis =f(x,y) system of two coupled differential equations y=g(x,y) step 1 find nullclines and fixed point(s)
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麻省理工大学:《Systems Biology》Review lecture 2 Michaelis-Menten kinetics
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