Content The“core Uniqueness of equilibrium Stability of equilibrium · Welfare

MAIN THEORIES ON PSYCHOLOGICAL DEVELOPMENT Learning Theory -Watson, Bandura Psychoanalytic Theory -Freud, Erikson Cognitive Development- Piaget

Ab initio =from the beginning in strictest sense uses first principles, not information about other protein structures In practice, all methods rely on empirical observations

1. Overview-the many levels of systems biology 2. Experimental methods for measuring protein-protein interactions and their limitations 3. Data sources for information about proteins and their

For a molecular simulation or model you need 1. a representation of the protein 2. An energy function 3. a search algorithm or optimizer

Review of protein structure hierarchy Nonpolar, Hydrophobic R-grou Primary structure Glycin (Gly, G) Aa,A≌ alina (VaL V. Leucine(Lou, L) Isoleucine{,非 MAAAAAAGPEMVRGQVE 20 amino acids Phenylalanine(Ph,月

Review of markov HMM Models for dna Markov Models for splice sites Hidden Markov models looking under the hood The Viterbi algorithm Real World HMMs

Markov Hidden markov models for dna Markov Models for splice sites Hidden Markov models looking under the hood The Viterbi algorithm Real World HMMs

Review of DNA Seq. Comparison/Alignment Target frequencies and mismatch penalties Eukaryotic gene structure Comparative genomics applications Pipmaker(2 species comparison) Phylogenetic Shadowing(many species) Intro to DNA sequence motifs

The Language of genomics CDNAS, ESTS. BACS Alus. etc Dideoxy Method Shotgun Sequencing The 'shotgun coverage equation(Poisson) Flavors of blast BLASTIPNXJ, TBLASTINXI Statistics of High Scoring Segments