Lecture 10: Bioengineering applications of hydrogels: Molecular Imprinting and Drug Delivery Last Day polyelectrolyte gels Polyelectrolyte complexes and multilayers Applications in bioengineering Theory of ionic gel swelling Toda Molecular imprinting

Lecture 6: Biodegradable Polymers for Tissue Engineering Last time: enzymatic degradation of solid polymers Engineering biological recognition of polymers Toda Designing polymers for tissue engineering Reading

Lecture 7: Hydrogel Biomaterials: Structure and Physical Chemistry Last Day: programmed/regulated/multifactor controlled release for drug delivery and tissue engineering

Lecture 7: Hydrogel Biomaterials: Structure and Physical Chemistry Last Day: programmed/regulated/multifactor controlled release for drug delivery and tissue engineering

Lecture 5: Controlled Release Devices Last time: Using enzyme substrate and cytokine peptides to engineer biological recognition of synthetic polymers Today: principles of controlled release devices based on degradable polymers Synthesis of controlled release devices Theory of polymer-based controlled release

Example: HIV-1 DNA vaccine delivered with boosters to elevate Ab titers2: Mechanical and electrical devices that can provide digitized release typically require larger devices and surgical implantation(e.g. Pharm. Res. 1, 237(1984); also have high cost

1. Re-derive the equation for equilibrium swelling of a polyelectrolyte gel where the polymer chains contain a basic ionizable group that becomes positively charged with decreasing pH

1. Re-derive the equation for equilibrium swelling of a polyelectrolyte gel where the polymer chains contain a basic ionizable group that becomes positively charged with decreasing pH

1. An early study in the development of peptide-presenting biomaterials showed that polymer surfaces bearing RGD peptides at a density equivalent to -10 peptides per each cell was sufficient to promote cell attachment, spreading and subsequent cell growth. In contrast, when whole

1.1 液态金属的短程有序结构 1.2 机械合金化制备的纳米非晶颗粒 1.3 液态金属纳米晶粒模型的建立 1.4 液态金属纳米晶粒模型的应用 1.5 结论 1.6 需做的工作