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MACINETIC RESONANCE ELSEVIER Progress in Nuclear Magnetic Resonance Spectroscopy 32(1998)287-387 The use of nmr methods for conformational studies of nucleic acids Sybren S. Wijmenga*, Bernd N M. van Buuren Umed University, Department of Medical Biochemistry and Biophysics, S 90187 Umed, Sweden
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NMR spectroscopy in structure-based drug design Gordon CK Roberts NMR methods for the study of motion in proteins continue Structure and dynamics of the binding site improve, and a n d complexes Methodological developments in NMR of macromolecules relevant to drug design
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NMR of drugs and ligands bound to receptors Anthony Watts NMR methods are now able to give detailed structural, dynamic of these still not identified or classed into families [4\]. and electronic information about drugs and ligands while
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TSINGHUA SCIENCE AND TECHNOLOGY ssN100702142325pp43-445 Volume 5, Number 4, December 2000 Interaction of Divalent Metal lons with the Adenosine Triphosphate Measured using nuclear magnetic resonance
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NMR supplement Hendrickson, W-A& Wuthrich, K Macromolecular 16. Leahy, D.J., Aukhil, I.& Erickson, H.P. 2.0 Cell 84 A K.D. thanks the Wellcome Trust and The queens 2D0i9 Riddiough. G. Nature Struct. Biol 18. sakaning. AK Kean. cel l8r.597-605i(eRw& by the Wellcome Trust. The authors acknowledge
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6 The noe effect c Gerd Gemmecker, 1999 Nuclear OVERHAUSER Effect(NOE): resonance line intensity changes caused by dipolare cross- relaxation from neighbouring spins with perturbed energy level populations To understand the nature of the NOE, we have to look at a two-spin system I' and
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4 DQF-COSY, Relayed-COSY, TOCSY Gerd Gemmecker 1999 Double-quantum filtered cOSY The phase problem of normal COsY can be circumvented by the dQF-COSY, using the MQc term generated by the second 90 pulse Ilz cos( @2t1) cos( t1) polarization
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2 Basis Principles of FT NMR C Gerd Gemmecker 1999 Nuclei in magnetic fields Atomic nuclei are composed of nucleons, i.e., protons and neutrons. Each of these particles shows a property named\spin\(behaving like an angular momentum) that adds up to the total spin of the
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蛋白的膜拓扑学研究 蛋白质的晶体学研究: X-ray; EM 蛋白质的单颗粒研究: EM; AFM 蛋白质结构的波谱技术:荧光; CD; NMR
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第一章光分析导论 1.1电磁辐射和电磁波谱 1.1.1.电磁辐射: 一种高速度通过空间传播的光量子流,它具有波粒二象性
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